

2006年9月-2010年6月 四川大學(xué)生物學(xué)基地班 學(xué)士
2010年9月-2015年7月 清華大學(xué)生命學(xué)院 博士
2015年10月-2020年10月 美國洛克菲勒大學(xué) 博士后
2020年10月-2021年3月 美國洛克菲勒大學(xué) 助理研究員
2021年3月至今? ?中國科學(xué)院生物與化學(xué)交叉研究中心 研究員、課題組長
張一小課題組致力于運(yùn)用冷凍電鏡技術(shù)研究富有挑戰(zhàn)性的生物學(xué)機(jī)制問題。蛋白質(zhì)、核酸、脂類等生物大分子是體內(nèi)各種生命活動的主要參與者,他們在體內(nèi)精密協(xié)同,執(zhí)行各種不同的生理功能。結(jié)構(gòu)生物學(xué)的研究通過解析這些生物大分子精細(xì)的三維結(jié)構(gòu),闡釋它們發(fā)揮功能的分子機(jī)制,并為相關(guān)藥物的研發(fā)和疾病的治療提供基礎(chǔ)。冷凍電鏡技術(shù)在近十年來發(fā)展十分迅速,已成為生物大分子結(jié)構(gòu)解析的主要手段。本課題組將綜合利用冷凍電鏡技術(shù)、生物化學(xué)、細(xì)胞生物學(xué)、神經(jīng)生物學(xué)等手段研究重要生物大分子的結(jié)構(gòu)與功能。
主要研究方向包括:
(1)與觸覺、聽覺等感知覺形成相關(guān)的機(jī)械力通道機(jī)制研究
(2)與神經(jīng)退行疾病相關(guān)的生物大分子復(fù)合物結(jié)構(gòu)與功能研究
(3)X染色體失活機(jī)制研究
1. “科技創(chuàng)新2030-腦科學(xué)與類腦研究”青年項(xiàng)目,主持,2022?
2. “上??萍记嗄?5人引領(lǐng)計(jì)劃”,2022
3. “國家優(yōu)青項(xiàng)目(海外)”,2021
4. 上海腦科學(xué)中心“求索杰出青年”課題組長,2021?
5. 中科院上海分院“青年英才培育計(jì)劃”,2021?
6. “上海市海外高層次人才引進(jìn)計(jì)劃”,2021?
1.?Han, Y., Zhou, Z., Jin, R., Dai, F., Ge, Y., Ju, X., Ma, X., He, S., Yuan, L., Wang, Y., Yang, W., Yue, X., Chen, Z., Sun, Y., Corry, B.# , Cox, C. D.#, and Zhang, Y.#?(2024). Mechanical activation opens a lipid-lined pore in OSCA ion channels. Nature, 1-9.
2.?Zhou, Z., Ma, X., Lin, Y., Cheng, D., Bavi, N., Secker, G.A., Li, J.V., Janbandhu, V., Sutton, D.L., Scott, H.S., Zhang, Y. #, Cox, C.D.#?(2023). MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels. Science,?381, 799-804.
3.?Yuan, L., Han, Y., Zhao, J., Zhang, Y.#, and Sun, Y#. (2023). Recognition and cleavage mechanism of intron-containing pre-tRNA by human TSEN endonuclease complex. Nature Communications,?14, 6071.
4.?Xia, A., Wang, X., He, J., Wu, W., Jiang, W., Xue, S., Zhang, Q., Gao, Y., Han, Y., and Li, Y., Peng, X., Xie, M., Mayer, C. T., Liu, J., Hua, C., Sha, Y., Xu, W., Huang, J., Ying, T., Jiang, S., Xie, Y., Cai, Q., Lu, L. #, Silva, I. T. #, Yuan, Z. #, Zhang, Y.?#, and Wang, Q#. (2023). Cross-reactive antibody response to Monkeypox virus surface proteins in a small proportion of individuals with and without Chinese smallpox vaccination history. BMC biology,?21, 205.
5.?Zhang, Y., Daday, C., Gu, R., Cox, C.D., Martinac, B., Groot, B., Walz, T. (2021). Visualizing the mechanosensitive ion channel MscS under membrane tension. Nature, 590, 509-514.
6.?Dan, J.*, Zhang, Y.*,?Lee, C.H., Valencia-Sanchez, M., Zhang, J., Wang, M., Holder, M., Svetlov, V., Tan, D., Nudler, E., Reinberg, D., Walz, T., Armache, K. (2021). Structures of monomeric and dimeric PRC:EZH1 reveal flexible modules involved in chromatin compaction. Nature Communications, 12(1): 714.
7.?Sun, Y.*, Zhang, Y.*, Aik, W.S., Yang, X.-C., Marzluff, W.F., Walz, T., Dominski, Z., and Tong, L. (2020). Structure of an active human histone pre-mRNA 3’-end processing machinery. Science?367, 700-703.
8.?Zhang, Y.*, Sun, Y.*, Shi, Y., Walz, T., and Tong, L. (2020). Structural Insights into the Human Pre-mRNA 3’-End Processing Machinery. Molecular Cell?77: 800-809.
9.?Su, M.*, Zhu, L.*, Zhang, Y.*, Paknejad, N.*, Dey, R., Huang, J., Lee, M.Y., Williams, D., Jordan, K.D., Eng, E.T., Ernst, O.P., Meyerson, J., Hite, R., Walz, T., Liu, W., Huang, X. (2020). Structural basis of the activation of heterotrimeric Gs-protein by isoproterenol-bound b1-adrenergic receptor. Molecular Cell?80:59-71.
10.?Ne?i?, D.*, Zhang, Y.*, Spasic, A.*, Li, J.*, Provasi, D., Filizola, M., Walz, T., and Coller, B.S. (2020). Cryo-Electron Microscopy Structure of the αIIbβ3-Abciximab Complex. Arteriosclerosis, Thrombosis, and Vascular Biology. 119.313671.
11.?Yu, J.*, Zhang, B.*, Zhang, Y.*, Xu, C.Q., Zhuo, W., Ge, J., Li, J., Gao, N., Li, Y., and Yang, M. (2018). A binding-block ion selective mechanism revealed by a Na/K selective channel. Protein & Cell?9, 629-639.
12.?Lees, J.A.*, Zhang, Y.*, Oh, M.S., Schauder, C.M., Yu, X., Baskin, J.M., Dobbs, K., Notarangelo, L.D., De Camilli, P., Walz, T., Renisch, K. (2017). Architecture of the human PI4KIIIalpha lipid kinase complex. Proc Natl Acad Sci.?U.S.A?114, 13720-13725.
13.?Sun, Y.*, Zhang, Y.*, Hamilton, K., Manley, J.L., Shi, Y., Walz, T., and Tong, L. (2017). Molecular basis for the recognition of the human AAUAAA polyadenylation signal. Proc Natl Acad Sci.?U.S.A?115, E1419-E1428.
14.?Zhang, Y., Ma, C., Yuan, Y., Zhu, J., Li, N., Chen, C., Wu, S., Yu, L., Lei, J., and Gao, N. (2014). Structural basis for interaction of a cotranslational chaperone with the eukaryotic ribosome. Nature Structural & Molecular Biology?21, 1042-1046.
15.?Wu, S., Tutuncuoglu, B., Yan, K., Brown, H., Zhang, Y., Tan, D., Gamalinda, M., Yuan, Y., Li, Z., Jakovljevic, J., et al. (2016). Diverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomes. Nature?534, 133-137.
16.?Li, N., Zhai, Y., Zhang, Y., Li, W., Yang, M., Lei, J., Tye, B.K., and Gao, N. (2015). Structure of the eukaryotic MCM complex at 3.8 A. Nature?524, 186-191.
* indicates co-first authors, #?indicates?co-corresponding authors