1990.9-1994.7?南開(kāi)大學(xué)環(huán)境科學(xué)系 學(xué)士
1994.9-1999.7中科院上海有機(jī)化學(xué)研究所 博士
1999.9-2000.3?中科院上海有機(jī)化學(xué)研究所 助理研究員
2000.3-2000.9?中科院上海有機(jī)化學(xué)研究所 副研究員
2000.9-2001.7?加州大學(xué)戴維斯分校?博士后
2001.7-2003.8?威斯康辛大學(xué)麥迪遜分校?研究助理
2003.8-至今 中科院上海有機(jī)化學(xué)研究所 研究員
現(xiàn)任中國(guó)科學(xué)院上海有機(jī)化學(xué)研究所生命過(guò)程小分子調(diào)控全國(guó)重點(diǎn)實(shí)驗(yàn)室課題組長(zhǎng)。
天然產(chǎn)物生物合成研究：以微生物來(lái)源的結(jié)構(gòu)新奇、活性顯著的復(fù)雜天然產(chǎn)物為目標(biāo)分子，從基因和蛋白水平揭示自然界神奇的生物化學(xué)過(guò)程，理解其中蘊(yùn)涵的新型酶催化反應(yīng)和生理拮抗機(jī)制；在此基礎(chǔ)上一方面通過(guò)化學(xué)-生物相結(jié)合的策略來(lái)創(chuàng)造“非天然”天然產(chǎn)物，另一方面通過(guò)生物合成與生物信息相關(guān)聯(lián)的方法激活沉默基因簇，進(jìn)而發(fā)現(xiàn)新的天然產(chǎn)物。復(fù)雜天然產(chǎn)物類(lèi)藥物的高效制備：以生物合成途徑為基礎(chǔ)，采用微生物合成生物學(xué)的方法和策略致力于提高目標(biāo)化合物的產(chǎn)量，改變發(fā)酵產(chǎn)物的組份及產(chǎn)生新化合物；進(jìn)而通過(guò)與化學(xué)半合成或生物催化相結(jié)合發(fā)展高效的制備路線。
中國(guó)科學(xué)院百人計(jì)劃(2004年)；
國(guó)家杰出青年基金(2004年)；
上海市科技啟明星和優(yōu)秀學(xué)術(shù)帶頭人基金(2005?2008?2014年)；
上海市科技創(chuàng)新領(lǐng)軍人才（2016年）；
“萬(wàn)人計(jì)劃”科技創(chuàng)新領(lǐng)軍人才（2016年）
1.?He, J.-B.; Wu, L.; Wei, W.; Meng, S.; Liu, Z.-T.; Wu, X.; Pan, H.-X.; Yang, S.; Liang, Y.*; Zhou, J.*;Tang, G.-L*. Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis. Nat. Catal.?2023, 6, 637-648.
2.?Chen, X.; Bradley, N. P.; Lu, W.; Wahl, K. L.; Zhang, M.; Yuan, H.; Hou, X.-F.; Eichman, B. F.*; Tang, G.-L.*?Base excision repair system targeting DNA adducts of trioxacarcin/LL-D49194 antibiotics for self-resistance. Nucleic Acids Res.?2022, 50, 2417–2430.
3.?Wen, W.-H.; Zhang, Y.; Zhang, Y.-Y.; Yu, Q.; Jiang, C.-C.; Tang, M.-C.; Pu, J.-Y.; Wu, L.; Zhao, Y.-L.; Shi, T.*; Zhou, J.*; Tang, G.-L.*?Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics. Nat. Commun. 2021, 12, 7085.
4.?Nie, Q.-Y.; Ji, Z.-Y.; Hu, Y.; Tang, G.-L.*?Characterization of highly reductive modification of tetracycline D?ring reveals enzymatic conversion of enone to alkane. ACS Catal.?2021, 11, 8399-8406.
5.?Wang, F.; Zhang,W.-H.; Zhao, J.; Kang, W.-J.; Wang, S.; Yu, B.; Pan, H.-X.*; Tang, G.-L.*?Characterization of miharamycin biosynthesis reveals a hybrid NRPS-PKS to synthesize high-carbon sugar from a complex nucleoside.?J. Am. Chem. Soc. 2020, 142, 5996-6000.
6.?Jin, W.-B.; Wu, S.; Xu, Y.-F.; Yuan, H.*; Tang, G.-L.*?Recent advances in HemN-like radicalS-adenosyl-L-methionine enzyme-catalyzed reactions.?Nat. Prod. Rep.?2020, 37, 17-28.
7.?Ji, Z.-Y.; Nie, Q.-Y.; Yin, Y.; Zhang, M.; Pan, H.-X.; Hou, X.-F.*; Tang, G.-L.*?Activation and characterization of cryptic gene cluster: Two series of aromatic polyketides biosynthesized by divergent pathways. Angew. Chem. Int. Ed.?2019, 58, 18046-18054.
8.?Zhang, Y.; Wen, W.-H.; Pu, J.-Y.; Tang, M.-C.; Zhang, L.; Pen, C.; Xu, Y.; Tang, G.-L.*?Extracellularly oxidative activation and inactivation of matured prodrug for cryptic self-resistance in naphthyridinomycin biosynthesis. Proc. Natl. Acad. Sci. U.S.A.?2018, 115, 11232–11237.
9.?Hou, X.-F.; Song, Y.-J.; Zhang, M.; Lan, W.; Meng, S.; Wang, C.; Pan, H.-X.; Cao, C.*; Tang, G.-L.*?Enzymology of anthraquinone-g-pyrone ring formation in complex aromatic polyketide biosynthesis. Angew. Chem. Int. Ed.?2018, 57, 13475-13479.
10.?Jin, W.-B.; Wu, S.; Jian, X.-H.; Yuan, H.*;?Tang, G.-L.* A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis. Nat. Commun.?2018, 9, 2771.
11.?Meng, S.; Han, W.; Zhao, J.; Jian, X.-H.; Pan, H.-X.*; Tang, G.-L.*?A six-oxidase cascade for tandem C-H bond activation revealed by reconstitution of bicyclomycin biosynthesis. Angew. Chem. Int. Ed.?2018, 57, 719-723.
12.?Yuan, H.; Zhang, J.; Cai, Y.; Wu, S.; Yang, K.; Stephen Chan, H. C.; Huang, W.; Jin, W.-B.; Li, Y.; Yin, Y.; Igarashi, Y.; Yuan, S.*; Zhou, J.*; Tang, G.-L.*?GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection. Nat. Commun.?2017, 8, 1485.
13.?Song, L.-Q.; Zhang, Y.-Y.; Pu, J.-Y.; Tang, M.-C.; Peng, C.;?Tang, G.-L.*?Catalysis of extracellular deamination by a FAD-linked oxidoreductase after prodrug maturation in the biosynthesis of saframycin A. Angew. Chem. Int. Ed.?2017,?56,?9116-9120.
14.?Zhang, Z.; Gong, Y.-K.; Zhou, Q.; Hu, Y.; Ma, H.-M.; Chen, Y.-S.; Igarashi, Y.; Pan, L.*; Tang, G.-L.*?Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade. Proc. Natl. Acad. Sci. U.S.A.?2017, 114, 1554–1559.
15.?He, H.-Y.; Yuan, H.; Tang, M.-C.; Tang, G.-L.*?An unusual dehydratase acting on glycerate and a ketoreducatse stereoselectively reducing α-ketone in polyketide starter unit biosynthesis. Angew. Chem. Int. Ed. 2014, 53, 11315-11319.
16.?He, H.-Y.; Tang, M.-C.; Zhang, F.; Tang, G.-L.*?Cis-Double bond formation by thioesterase and transfer by ketosynthase in FR901464 biosynthesis. J. Am. Chem. Soc. 2014, 136,?4488-4491.
17.?Xu, H.; Huang, W.; He, Q.-L.; Zhao, Z.-X.; Zhang, F.; Wang, R.; Kang, J.; Tang, G.-L.*?Self-resistance to antitumor antibiotic: a DNA glycosylase triggers the base excision repair system in yatakemycin biosynthesis. Angew. Chem. Int. Ed. 2012, 51, 10532-10536.
18.?Huang, W.; Xu, H.; Li, Y.; Zhang, F.; Chen, X.-Y.; He, Q.-L.; Igarashi, Y.; Tang, G.-L.*?Characterization of yatakemycin gene cluster revealing a radical SAM-dependent MT and highlighting spirocyclopropane biosynthesis. J. Am. Chem. Soc. 2012, 134, 8831-8840.
19.?Peng, C.; Pu, J.-Y.; Song, L.-Q.; Jian, X.-H.; Tang, M.-C.; Tang, G.-L.*?Hijacking a hydroxyethyl unitfrom a central metabolic ketose into a nonribosomal peptide assembly line. Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 8540-8545.
20.?Zhang, F.; He, H.-Y.; Tang, M.-C.; Zhou, Q.;?Tang, G.-L.*?Cloning and elucidation of the FR901464 gene cluster revealing a complex AT-less PKS using glycerate as starter units.?J. Am. Chem. Soc.?2011,?133, 2452-2462.
