2001年9月~ 2005年7月，復(fù)旦大學(xué)化學(xué)系，學(xué)士
2005年9月~ 2010年6月，香港科技大學(xué)生物化學(xué)系，博士
2010年7月~ 2011年2月，香港科技大學(xué)生命科學(xué)部，助理研究員
2011年3月~ 2012年8月，香港科技大學(xué)生命科學(xué)部，研究助理教授
2013年1月~ 2013年4月，美國哈佛大學(xué)醫(yī)學(xué)院，訪問學(xué)者
2012年8月~至今，中國科學(xué)院上海有機(jī)化學(xué)研究所，研究員
現(xiàn)任中國科學(xué)院上海有機(jī)化學(xué)研究所生命過程小分子調(diào)控全國重點(diǎn)實(shí)驗(yàn)室課題組長。
1.以人類疾病為導(dǎo)向，綜合利用結(jié)構(gòu)生物學(xué)、化學(xué)生物學(xué)、生物化學(xué)等多手段的交叉學(xué)科研究，具體包括：研究與癌癥、神經(jīng)退行性疾病相關(guān)的細(xì)胞自噬通路，揭示相關(guān)未知的分子機(jī)制和致病機(jī)理；研究與疾病相關(guān)的重要E3泛素酶和去泛素酶的結(jié)構(gòu)與作用機(jī)制，并研發(fā)相關(guān)的小分子調(diào)節(jié)劑和靶向降解技術(shù)，用于后續(xù)相關(guān)的化學(xué)生物學(xué)和潛在的疾病治療研究。
2.活性小分子的化學(xué)生物學(xué)研究，具體包括：天然活性小分子與靶點(diǎn)蛋白相互作用的機(jī)制研究；重要生物合成酶與小分子的互作機(jī)制以及相關(guān)的催化反應(yīng)機(jī)理研究。
中國科學(xué)院朱李月華優(yōu)秀教師獎（2021）
上海市青年五四獎?wù)拢?020）
上海市學(xué)術(shù)帶頭人項(xiàng)目（2020）
上海市科技系統(tǒng)青年五四獎?wù)拢?019）
國家自然科學(xué)基金委員會優(yōu)秀青年科學(xué)基金（2018）
中國化學(xué)會青年化學(xué)獎（2017）
上海市科技啟明星計(jì)劃（2013）
國家“千人計(jì)劃（青年項(xiàng)目）”?（2013）
1.?Zhang Y, Sun Y, Shi J, Xu P, Wang Y, Liu J, Gong X, Wang Y, Tang Y, Liu H, Zhou X, Lin Z, Baba O, Morita T, Yu B*, Pan L* "Decoding the molecular mechanism of selective autophagy of glycogen mediated by autophagy receptor STBD1" PNAS. 2024 (in presss).
2.?Zhang M, Wang Y, Gong X, Wang Y, Zhang Y, Tang Y, Zhou X, Liu H, Huang Y, Zhang J,?Pan L*?"Mechanistic insights into the interactions of TAX1BP1 with RB1CC1 and mammalian ATG8 family proteins"?PNAS.?2024, 121(11):e2315550121.
3.?Xu X, Wang Y, Zhang Y, Wang Y, Yin Y, Peng C, Gong X, Li M, Zhang Y, Zhang M, Tang Y, Zhou X, Liu H, Pan L* "Mechanistic insights into the enzymatic activity of E3 ligase HOIL-1L and its regulation by the linear ubiquitin chain-binding" Science Advances. 2023, 9(41):eadi4599.
4.?Zhang T, Xu D, Trefts E, Lv M, Liu J, Liu M, Chu C, Wang M, Wang H, Meng H, Liu H, Zhuang Y, Xie X, Dang F, Jiang C, Dai X, Lee Y, Inuzuka H, Erickson E, Hillis A, Dibble C, Miao J, Asara J, Szabo G, Sicinski P, Pan L*, Shaw R*, Yuan J*, and Wei W* "Metabolic Orchestration of Necroptosis and Inflammation through AMPK-Mediated Phosphorylation of RIPK1" Science.?2023,?380, 1372-1380.
5.?Gong?X, Wang?Y, Tang?Y, Wang?Y, Zhang?M, Li?M, Zhang?Y, Pan L* "ATG16L1 adopts a dual-binding-site mode to interact with WIPI2b in autophagy"?Science Advances.?2023, 9(9):eadf0824.
6.?Feng K, Zhang Y, Zhang M, Yang Y, Liu J, Pan L*, Zeng Y* "A flavin-monooxygenase catalyzing oxepinone formation and the complete biosynthesis of vibralactone" Nature Communications. 2023, 14(1):3436.
7.?Wang?H, Zou?Y, Li?M, Tang?Z, Wang?J, Tian?Z, Strassner?N, Yang?Q, Zheng?Q, Guo?Y, Liu?W*, Pan?L*,?and Houk?K*?"A Cyclase that Catalyses Competing 2+2 and 4+2 Cycloadditions" Nature Chemistry. 2023, 15(2):177-184.
8.?Liu J*, Wang Y, Wang D, Wang Y, Xu X, Zhang Y, Li Y, Zhang M, Gong X, Tang Y, Li M,?Pan L*?"Mechanistic insights into the subversion of the linear ubiquitin chain assembly complex by the E3 ligase IpaH1.4 of Shigella flexneri"?PNAS.?2022, 119(12):e2116776119.
9.?Fu T, Zhang M, Zhou Z, Wu P, Peng C, Wang Y, Gong X, Li Y, Wang Y, Xu X, Li M, Shen L, Pan L* "Mechanistic insights into the recruitment of the autophagy-initiating ULK and TBK1 complexes by autophagy receptor NDP52"?Science Advances. 2021, 7(33):eabi6582.
10.?Zhou Z, Liu J, Fu T, Wu P, Peng C, Gong X, Wang Y, Zhang?M, Li Y, Wang?Y, Xu?X, Li M, Pan L* "Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation"?Nature Communications. 2021, 12(1):1570.?(Recommended by Faculty Opinions)
11.?Li Y, Cheng Y, Li M, Wang Y, Fu T, Zhou Z,?Wang Y,?Gong X, Xu X, Liu J, Pan L* "Decoding three distinct states of the Syntaxin17 SNARE motif in mediating the autophagosome-lysosome fusion"?PNAS. 2020,?117, 21391-21402.?(Recommended by Faculty Opinions)
12.?Hu S, Guo Y, Wang?Y, Li Y, Fu T, Zhou Z, Wang Y, Liu J, Pan L* "Structure of Myosin VI/Tom1 complex reveals a cargo recognition mode of Myosin VI for tethering"?Nature Communications. 2019, 10(1):3459.?
13.?Fu?T, Liu?J, Wang?Y, Xie?X, Hu?S, Pan L* "Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1"?PNAS.?2018, 115, E11651-E11660.
14.?Li F, Xu D, Wang Y, Zhou Z, Liu J, Hu S, Gong Y, Yuan J, Pan L* "Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation" Autophagy. 2018, 14, 66-79.?
15.?Liu J, Wang Y, Gong Y,?Fu T,?Hu S, Zhou Z, Pan L* "Structural Insights into SHARPIN-mediated Activation of HOIP for the Linear Ubiquitin Chain Assembly" Cell Reports. 2017, 21(1):27-36.?
16.?Zhang Z, Gong YK, Zhou Q, Hu Y, Ma HM, Chen YS, Igarashi Y, Pan L*,?Tang G* "Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade"?PNAS. 2017, 114,?1554-1559.
17.?Cheng X, Wang Y, Gong Y, Li F, Guo Y, Hu S, Liu J, Pan L* "Structural Basis of FYCO1 and MAP1LC3A Interaction Reveals a Novel Binding Mode for Atg8 Family Proteins" Autophagy. 2016, 12, 1330-1339.
18.?Li F, Xie X,?Wang Y, Liu J,?Cheng X, Guo Y, Gong Y, Hu S, Pan L* "Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins"?Nature Communications.?2016, 7:12708.
19.?Xie?X, Li?F, Wang Y, Wang?Y, Lin?Z, Cheng?X, Liu?J, Chen?C,?Pan?L*?"Molecular Basis of Ubiquitin Recognition by Autophagy Receptor CALCOCO2"?Autophagy.?2015, 10, 1775-1789. ?
20.?Wu L#, Pan L#, Wei Z, Zhang M* "Structure of MyTH4-FERM Domains in Myosin VIIa Tail Bound to Cargo" Science.?2011,?331,?757-760.?(#:co-first authors,?highlighted by Faculty of 1000,?F1000 Cell Biology and F1000 Genomics & Genetics)
