

李序文,研究員,博士生導(dǎo)師,課題組長,優(yōu)青。2013年獲得法國巴黎第六大學(xué)(UPMC,皮埃爾和瑪麗居里大學(xué))分子化學(xué)專業(yè)博士學(xué)位,2013-2015年分別在法國國家科學(xué)研究中心(CNRS)和瑞士蘇黎世聯(lián)邦理工大學(xué)(ETH Zurich)從事博士后研究。2015年回國加入中國科學(xué)院上海藥物研究所從事海洋天然藥物化學(xué)方面的課題研究。目前已在國際知名期刊Angew. Chem. Int. Ed., Nat. Prod. Rep., J. Med. Chem., Org. Lett., Chem. Eur. J.等以第一作者或通訊作者發(fā)表60余篇SCI論文,同時作為JMC, OL, APSB, Mar. Drugs, CCL, TL, BMCL等雜志特邀審稿人。擔(dān)任中國藥學(xué)會海洋藥物專業(yè)委員會委員,上海市藥學(xué)會海洋藥物專業(yè)委員會副主任委員和天然藥化專業(yè)委員會委員秘書,上海市醫(yī)藥衛(wèi)生青年聯(lián)合會第二屆委員會委員,藥學(xué)學(xué)報、APSB、CCL、CJNM等權(quán)威期刊青年編委。
1. 新穎海洋天然產(chǎn)物發(fā)現(xiàn)和復(fù)雜分子的結(jié)構(gòu)解析
2. 活性天然產(chǎn)物的仿生合成、功能導(dǎo)向合成和靶標垂釣
3. 基于藥用物質(zhì)基礎(chǔ)的海洋生物資源和海洋中藥的合理開發(fā)利用?
1.上??萍记嗄?5人引領(lǐng)計劃獲選者(2021)
2.中國藥學(xué)會-施維雅青年藥物化學(xué)獎(2019)
3.賽諾菲-中國科學(xué)院上海生命科學(xué)研究院優(yōu)秀青年人才獎勵基金(2017)
1.國家重點研發(fā)計劃青年科學(xué)家項目(2021YFF0502400),特色海洋軟體動物及其食源生物中活性分子的高效挖掘和成藥性研究,課題負責(zé)人(2021.12-2026.11)
2.國家自然科學(xué)基金優(yōu)秀青年科學(xué)基金項目(8202290170),海洋天然藥物化學(xué),課題負責(zé)人(2021.01-2023.12)
3.國家自然科學(xué)基金面上項目(42076099),中國南海深遠海短足軟珊瑚中cladiellin型二萜的化學(xué)多樣性及靶向EGFR抗腫瘤活性研究,課題負責(zé)人(2021.01-2024.12)
4.國家自然科學(xué)基金國際合作與交流項目(8171101331),中國南海軟體動物中化學(xué)成分的發(fā)現(xiàn),功能導(dǎo)向合成及腫瘤多靶點抑制活性的篩選,課題負責(zé)人,結(jié)題
5.中國科學(xué)院青年創(chuàng)新促進會優(yōu)秀會員(Y202065),2021.01-2023.12(人才基金)
6.上海市科技啟明星計劃(A類)(20QA1411100),2020.06-2023.05(人才基金)
7.上海市浦江人才計劃(16PJ1410600),2016.07-2018.06(人才基金)
8.中國科學(xué)院青年創(chuàng)新促進會會員(2016258),2016.01-2019.12(人才基金)
9.中國科協(xié)“青年人才托舉工程”(2016QNRC001),2015.01-2017.12(人才基金)
1.Qi-Hao Wu1, Song-Wei Li1, Heng Xu1, Hong Wang, Pei Hu, Hao Zhang, Cheng Luo, Kai-Xian Chen, Bastien Nay*, Yue-Wei Guo*,?Xu-Wen Li*. Complex Polypropionates from a South China Sea Photosynthetic Mollusk: Isolation and Biomimetic Synthesis Highlighting Novel Rearrangements.?Angew. Chem. Int. Ed.?2020, 59, 12105-12112.
2.Cheng-Long Gao1, Gui-Ge Hou1, Jin Liu1, Tong Ru, Ya-Zhou Xu, Shun-Yi Zhao, Hui Ye, Lu-Yong Zhang, Kai-Xian Chen, Yue-Wei Guo*, Tao Pang*,?Xu-Wen Li*. Synthesis and Target Identification of Benzoxepane Derivatives as Potential Anti-Neuroinflammatory Agents for Ischemic Stroke.?Angew. Chem. Int. Ed. 2020, 59, 2429-2439.
3.Jin Liu1, Heng Li1, Kai-Xian Chen, Jian-Ping Zuo, Yue-Wei Guo,* Wei Tang,*?Xu-Wen Li*. Design and Synthesis of Marine Phidianidine Derivatives as Potential Immunosuppressive Agents.?J. Med. Chem. 2018, 61, 11298-11308.
4.Geng Li, Heng Li, Wei Tang, Yue-Wei Guo*,?Xu-Wen Li*. Klyflaccilids A and B, Diterpenoids with 6/5/8/3 Fused Tetracyclic Carbon Skeleton from Hainan Soft Coral Klyxum flaccidum.?Org. Lett.?2019, 21, 5660-5664.
5.Zi-Hui Chen, Wang-Sheng Li, Zai-Yong Zhang, Hui Luo, Jian-Rong Wang, Hai-Yan Zhang*, Zi-Rong Zeng, Bao Chen,?Xu-Wen Li* and Yue-Wei Guo*. Sinusiaetone A, an Anti-inflammatory Norditerpenoid with a Bicyclo[11.3.0]hexadecane Nucleus from the Hainan Soft Coral Sinularia siaesensis.?Org.Lett.?2021, 23, 5621-5625.
6.Zi-Rong Zeng, Wang-Sheng Li, Bastien Nay, Pei Hu, Hai-Yan Zhang*, Hong Wang*,?Xu-Wen Li*, Yue-Wei Guo*. Sinunanolobatone A, an Anti-inflammatory Diterpenoid with Bicy-clo[13.1.0]pentadecane Carbon Scaffold, and Related Casbanes from the Sanya Soft Coral Sinularia nanolobata.?Org. Lett. 2021, 23, 19, 7575-7579.?
7.Fei Ye, Jing Li, Yu Wu, Zheng-Dan Zhu, Ernesto Mollo, Margherita Gavagnin, Yu-Cheng Gu, Wei-Liang Zhu,?Xu-Wen Li,* Yue-Wei Guo*. Sarinfacetamides A and B, Nitrogenous Diterpenoids with Tricyclo[6.3.1.01,5]dodecane Scaffold from the South China Sea Soft Coral Sarcophyton infundibuliforme.?Org. Lett.?2018, 20, 2637-2640.
8.Fei Ye, Zheng-Dan Zhu, Jun-Sheng Chen, Jing Li, Yu-Cheng Gu, Wei-Liang Zhu,?Xu-Wen Li,* Yue-Wei Guo*. Xishacorenes A-C, Diterpenes with Bicyclo[3.3.1]nonane Nucleus from the Xisha Soft Coral Sinularia polydactyla. Org. Lett. 2017, 19, 4183-4186.
9.Dong-Yu Sun, Guan-Ying Han, Jing-Xu Gong, Bastien Nay, Xu-Wen Li,* Yue-Wei Guo*. Asymmetric Total Synthesis of Distaminolyne A and Revision of Its Absolute Configuration.?Org. Lett.?2017, 19, 714-717.
10.Xu-Wen Li, Bastien Nay*. Transition metal-promoted biomimetic steps in total syntheses.?Nat. Prod. Rep. 2014, 31, 533-549.
11.Xu-Wen Li, Alexandre Ear, Bastien Nay*. Hirsutellones and beyond: figuring out the biological and synthetic logics toward chemical complexity in fungal PKS-NRPS compounds.?Nat. Prod. Rep. 2013, 30, 765-782.
12.Xu-Wen Li, Alexandre Ear, Lukas Roger, Dr. Nassima Riache, Alexandre Deville, Dr. Bastien Nay*. Bio-inspired formal synthesis of hirsutellones A-C featuring an electrophilic cyclization triggered by remote Lewis acid-activation.?Chem. Eur. J. 2013, 19, 16389-16393.