

陳以昀博士,現(xiàn)任中國科學院上海有機化學研究所生命過程小分子調(diào)控全國重點實驗室研究員、課題組長,同時兼任上??萍即髮W物質(zhì)學院教授。他于北京大學獲得化學學士學位,在普林斯頓大學取得有機化學博士學位,并在哈佛大學和霍華德休斯醫(yī)學研究所進行博士后研究。陳博士的研究興趣集中于生物相容光化學領域,致力于有機光化學與光化學生物學的研究。
生物相容光化學:有機光化學,光化學生物學
中國科學院大學優(yōu)秀授課教師,中國,2022
藥明康德生命化學研究獎,中國,2021
上海市科技系統(tǒng)青年五四獎章,中國,2018
Thieme化學期刊獎,德國,2018
中國光化學優(yōu)秀青年科學家獎,中國,2017
普林斯頓大學百時美施貴寶研究生合成化學獎,美國,2005
國家自然科學基金委員會重點項目,上海市優(yōu)秀學術帶頭人計劃,中國科學院創(chuàng)新交叉團隊,國家自然科學基金委員會優(yōu)秀青年科學基金項目,上海市浦江人才計劃項目
1.???? Zou, P.1; Fu, D.1; Wang, H.1; Sun, R.; Lan, Y.*; Chen, Y.*? Photochemical 1,3-Boronate Rearrangement Enables Three-Component N-Alkylation for α-Tertiary Hydroxybenzylamine Synthesis. Nat. Commun. 2024, 15, 10234.
2.???? Dong, X.1; Shao, Y.1; Liu, Z.; Huang, X.; ?Xue, X.*; Chen, Y.*? Radical 6-Endo Addition Enables Pyridine Synthesis under Metal-Free Conditions. Angew. Chem., Int. Ed. 2024, 63, e202410297.
3.???? Zeng, K.1; Jiao, Z.1; Jiang, Q.; He, R.; Zhang, Y.; Li, W.*; Xu, T.*; Chen, Y.*? Genetically Encoded Photocatalysis Enables Spatially Restricted Optochemical Modulation of Neurons in Live Mice. ?ACS Cent. Sci. 2024, 10, 1, 163–175. ??
4.???? Hao, K.1; Li, D.1; Fu, D.; Zou, P.; Xie, S.; Lan, Y.*; Chen, Y.*? Metal-Free 1,3-Boronate Rearrangement to Ketones Driven by Visible Light. Angew. Chem., Int. Ed. 2024, 63, e202316481.
5.???? Liu, D.1; Yang, K.1; Fang, D.1; Li, S.; Lan, Y.*; Chen, Y.* Formyl Radical Generation from α-Chloro N-Methoxyphthalimides Enables Selective Aldehyde Synthesis. Angew. Chem., Int. Ed. 2023, 62, e202213686.
10.?? Zhang, J.; Li, Y.; Xu, R.; Chen, Y.*? Donor-Acceptor Complex Enables Alkoxyl Radical Generation for Metal-Free C(sp3)-C(sp3) Cleavage and Allylation/Alkenylation. Angew. Chem., Int. Ed. 2017, 56, 12619?12623.
11.?? Jia, K.; Pan, Y.; Chen, Y.*? Selective Carbonyl-C(sp3) Bond Cleavage to Construct Ynamides, Ynoates, and Ynones by Photoredox Catalysis. Angew. Chem., Int. Ed. 2017, 56, 2478–2481.
12.?? Qi, L.; Chen, Y.*?Polarity-Reversed Allylations of Aldehydes, Ketones, and Imines Enabled by Hantzsch Ester in Photoredox Catalysis. Angew. Chem., Int. Ed. 2016, 55, 13312?13315.
13.?? Jia, K.; Zhang, F.; Huang, H.; Chen, Y.* Visible-Light-Induced Alkoxyl Radical Generation Enables Selective C(sp3)-C(sp3) Bond Cleavage and Functionalizations. J. Am. Chem. Soc. 2016, 138, 1514?1517.
14.?? Zhang, J.; Li, Y.; Zhang, F.; Hu, C.; Chen, Y.* Generation of Alkoxyl Radicals by Photoredox Catalysis Enables Selective C(sp3)-H Functionalization under Mild Reaction Conditions. Angew. Chem., Int. Ed. 2016, 55, 1872?1875.
15.?? Huang, H.1; Zhang, G.1; Chen, Y.* Dual Hypervalent Iodine(III) Reagents and Photoredox Catalysis Enable Decarboxylative Ynonylation under Mild Conditions. Angew. Chem., Int. Ed. 2015, 54, 7872?7876.
16.?? Huang, H.; Jia, K.; Chen, Y.* Hypervalent Iodine Reagents Enable Chemoselective Deboronative/Decarboxylative Alkenylation by Photoredox Catalysis. Angew. Chem., Int. Ed. 2015, 54, 1881?1884.
18.?? Dumelin, C.; Chen, Y.; Leconte, A. M.; Chen, Y. G.; Liu, D. R.*, Discovery and Biological Characterization of Geranylated RNA in Bacteria. Nat. Chem. Bio. 2012, 8, 913?919.
19.?? Chen, Y.; Kamlet, A. S.; Steinman, J. B.; Liu, D. R.*, A Biomolecule-Compatible Visible-Light-Induced Azide Reduction from a DNA-Encoded Reaction-Discovery System. Nature Chem. 2011, 3, 146?153.
20.?? Chen, Y.; Ho, D. M.; Lee, C.*, Ruthenium-Catalyzed Hydrative Cyclization of 1,5-Enynes. J. Am. Chem. Soc. 2005, 127, 12184?12185.