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姓 名: |
馬大為 |
性 別: |
男 |
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職 稱: |
研究員 |
學 歷: |
研究生 |
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電 話: |
021-54925130 |
傳 真: |
021-64166128 |
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電子郵件: |
madw@mail.sioc.ac.cn |
個人主頁: |
http://daweima.sioc.ac.cn |
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通訊地址: |
上海市零陵路345號生命有機國家重點實驗室 200032 |
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| 簡歷: |
1984年畢業(yè)于山東大學化學系;
1989年于中國科學院上海有機化學研究所獲博士學位;
1990-1994年在美國匹茲堡大學化學系和Mayo Clinic神經(jīng)化學和神經(jīng)生物學研究部進行博士后研究;
現(xiàn)任中國科學院上海有機化學研究所研究員、課題組長。 |
| 研究方向: |
具有重要生理活性的復雜天然產(chǎn)物的全合成及結(jié)構(gòu)-活性關(guān)系研究;
針對特殊靶點如G-蛋白偶連受體,蛋白激酶,蛋白水解酶和細胞凋亡過程的小分子調(diào)節(jié)劑的發(fā)現(xiàn);
有機合成方法學的發(fā)展和其在合成生物活性分子中的應用。 |
| 獲獎及榮譽: |
求是科技基金會杰出青年學者獎(1998);
中國青年科技獎 (1998);
上海市十大杰出青年(2001);
上海市科學進步一等獎(2005);
國家自然科學二等獎 (2007);
第七屆上海市自然科學牡丹獎 (2009)
上海市科技精英(2009)
N. C. Yang Lecturer Award (2016)
美國化學會Arthur C. Cope 學者獎(2018)
未來科學大獎物質(zhì)科學獎(2018) |
| 代表論著: |
1. Pingluan Wang, Yang Gao, Dawei Ma* Divergent Entry to Gelsedine-Type Alkaloids: Total Syntheses of (?)-Gelsedilam, (?)-Gelsenicine, (?)-Gelsedine, and (?)-Gelsemoxonine. J. Am. Chem. Soc. 2018, 140, 11608?11612.
2. Dongshun Ni, Yi Wei, Dawei Ma*, Thiourea‐Catalyzed Asymmetric Michael Addition of Carbazolones to 2‐Chloroacrylonitrile: Total Synthesis of 5,22‐Dioxokopsane, Kopsinidine C, and Demethoxycarbonylkopsin, Angew. Chem. Int. Ed. 2018, 57, 10207 –10211.
3. Jie Liu, Dawei Ma* A Unified Approach for the Assembly of Atisine- and Hetidine-type Diterpenoid Alkaloids: Total Syntheses of Azitine and the Proposed Structure of Navirine C Angew. Chem. Int. Ed. 2018, 57, 6676 –6680.
4. Yang Gao, Mengyang Fan, Qixiang Geng, Dawei Ma* Total Synthesis of Lapidilectine B Enabled by Manganese(III)‐Mediated Oxidative Cyclization of Indoles. Chem. Eur. J. 2018, 24, 6547–6550.
5. Jinlong Zhao, Songtao Niu, Xi Jiang, Yongwen Jiang, Xiaojing Zhang, Tiemin Sun, Dawei Ma* A Class of Amide Ligands Enable Cu-Catalyzed Coupling of (Hetero)aryl Halides with Sulfinic Acid Salts under Mild Conditions J. Org. Chem. 2018, 83, 6589?6598.
6. S. Vijay Kumar, Dawei Ma* Synthesis of N?(Hetero)aryl Carbamates via CuI/MNAO Catalyzed Cross-Coupling of (Hetero)aryl Halides with Potassium Cyanate in Alcohols J. Org. Chem. 2018, 83, 2706?2713
7. Subhajit Bhunia, Govind Goroba Pawar, S. Vijay Kumar, Yongwen Jiang and Dawei Ma* Selected Copper-Based Reactions for C-N, C-O, C-S and C-C Bond Formation. Angew. Chem. Int. Ed. 2017, 56, 16136–16179
8. Xiangbo Zhao, Wu Li, Junjie Wang, Dawei Ma* Convergent Route to ent-Kaurane Diterpenoids: Total Synthesis of Lungshengenin D and 1α,6α-Diacetoxy-ent-kaura-9(11),16-dien-12,15-dione. J. Am. Chem. Soc. 2017, 139, 2932-2935
9. Yuntong Zhai, Xiaofei Chen, Wei Zhou, Mengyang Fan, Yisheng Lai, and Dawei Ma*, Copper-Catalyzed Diaryl Ether Formation from (Hetero)aryl Halides at Low Catalytic Loadings. J. Org. Chem. 2017, 82, 4964.
10.Jie Gao, Subhajit Bhunia, Kailiang Wang, Lu Gan, Shanghua Xia, and Dawei Ma*, Discovery of N-(Naphthalen-1-yl)-N’-alkyl Oxalamide Ligands Enables Cu-Catalyzed Aryl Amination with High Turnovers, Org. Lett. 2017, 19, 2809.
11.Shanghua Xia, Lu Gan, Kailiang Wang, Zheng Li, Dawei Ma*, Copper-Catalyzed Hydroxylation of (Hetero)aryl Halides under Mild Conditions, J. Am. Chem. Soc. 2016, 138, 13492.
12.Mengyang Fan, Wei Zhou, Yongwen Jiang, Dawei Ma*, Diaryl Ether Formation through CuI/Oxalic Diamide Catalyzed Coupling of (Hetero)aryl Chlorides and Phenols, Angew. Chem. Int. Ed. 2016, 55, 6211.
13.Mengyang Fan, Wei Zhou, Yongwen Jiang, Dawei Ma*, Assembly of Primary (Hetero)Arylamines via CuI/Oxalic Diamide-Catalyzed Coupling of Aryl Chlorides and Ammonia, Org. Lett. 2015, 17, 5934.
14.Wei Zhou, Mengyang Fan, Junli Yin, Yongwen Jiang, Dawei Ma*, CuI/Oxalic Diamides Catalyzed Coupling Reaction of (Hetero)Aryl Chlorides and Amines, J. Am. Chem. Soc. 2015, 137, 11942.
15.Weiwei Zi, Zhiwei Zuo, Dawei Ma*, Intramolecular dearomative oxidative coupling of indoles: A unified strategy for the total synthesis of indoline alkaloid, Acc. Chem. Res. 2015, 48, 702.
16.Junshan Tian, Jiankang Zhong, Yunsheng Li, Dawei Ma*, Organocatalytic and Scalable Synthesis of Anti-flu Drugs Zanamivir, Laninamivir and CS-8958, Angew. Chem. Int. Ed. 2014, 53, 13885.
17.Shaolin Zhu, Shouyun Yu, You Wang and Dawei Ma*, Organocatalytic Michael addition of aldehydes to protected 2-amino-1-nitroethenes: Application in a practical synthesis of Oseltamivir (Tamiflu) and γ-substituted 3-aminopyrrolidine, Angew. Chem. Int. Ed. 2010, 49, 4656.
18.Dawei Ma*, Cai Qian, Copper/amino acid catalyzed cross-couplings of aryl and vinyl halides with nucleophiles, Acc. Chem. Res. 2008, 41, 1450.
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