1988年9月-1992年7月，四川大學(xué)生物工程系微生物專業(yè),學(xué)士學(xué)位；
1994年9月---1997年7月，中國(guó)協(xié)和醫(yī)科大學(xué)（中國(guó)醫(yī)學(xué)科學(xué)院），碩士學(xué)位；
1997年9月---2000年7月；中國(guó)協(xié)和醫(yī)科大學(xué)（中國(guó)醫(yī)學(xué)科學(xué)院）博士學(xué)位（美國(guó)加州大學(xué)戴維斯分校化學(xué)系聯(lián)合培養(yǎng)）；
2000年9月---2001年8月，美國(guó)加州大學(xué)戴維斯分?；瘜W(xué)系(DepartmentofChemistry,UniversityofCalifornia-Davis)，博士后；
2001年9月---2003年8月，美國(guó)威斯康星大學(xué)麥迪遜分校藥學(xué)院(School of Pharmacy,University of Wisconsin-Madison)，研究助理；
2003年8月-至今，中國(guó)科學(xué)院上海有機(jī)化學(xué)研究所，研究員。
復(fù)雜天然產(chǎn)物的生物合成（遺傳學(xué)、生物化學(xué)和化學(xué)）研究
以產(chǎn)量提高和結(jié)構(gòu)多樣性為目的組合生物合成研究
以基因組挖掘?yàn)槭侄蔚男滦吞烊划a(chǎn)物發(fā)現(xiàn)研究
2019年 上海市自然科學(xué)獎(jiǎng)一等獎(jiǎng)（單位排名第一、個(gè)人排名第一）
2015年 談家楨生命科學(xué)獎(jiǎng)創(chuàng)新獎(jiǎng)
2013年 日本化學(xué)會(huì)The Distinguished Lectureship Award
2010年 明知乳業(yè)生命科學(xué)獎(jiǎng)優(yōu)秀獎(jiǎng)
2008年 上海市科技進(jìn)步獎(jiǎng)一等獎(jiǎng)（單位排名第三、個(gè)人排名第五）
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1.?????? Botao Cheng#, Jiwu Huang#, Yuting Duan, Wen Liu*. Association of radical chemistry with LanD flavoprotein activity for C-terminal macrocyclization of a ribosomal peptide through the formation of an unsaturated thioether residue. Angewandte Chemie-International Edition 2023, 62(35), e202308733.
2.?????? Zhijun Tang#, Bo Pang#, Chang Liu#, Shengjie Guo, Xudong Qu, Wen Liu*. Formation and loading of a (2S)-2-ethylmalonamyl starter unit in the assembly line of polyketide-nonribosomal peptide hybrid sanglifehrin A. Angewandte Chemie-International Edition 2023, 62(23), e202217090.
3.?????? Hongbo Wang#, Yike Zou#, Miao Li#, Zhijun Tang#, Jiabao Wang, Zhenhua Tian, Nina Strassner, Qian Yang, Qingfei Zheng, Yujiao Guo, Wen Liu*, Lifeng Pan*, K. N. Houk*. A cyclase that catalyses competing 2 + 2 and 4 + 2 cycloadditions. Nature Chemistry 2023, 15(2), 177-184.
4.?????? Yiyuan Cheng, Xuan Yi, Yan Zhang, Qingli He, Dandan Chen, Weiguo Cao, Pengfei Fang*, Wen Liu*. Oxidase heterotetramer completes 1？azabicyclo[3.1.0]hexane formation with the association of a nonribosomal peptide synthetase. Journal of the American Chemical Society 2023, 145(16), 8896-8907.
5.?????? Yanqing Xue#, Xiaofeng Wang#, Wen Liu*. Reconstitution of the linaridin pathway provides access to the family-determining activity of two membrane-associated proteins in the formation of structurally underestimated cypemycin. Journal of the American Chemical Society 2023, 145(12), 7040-7047.
6.?????? Shengjie Guo, Yueqian Sang, Chao Zheng, Xiao-Song Xue, Zhijun Tang*, Wen Liu*. Enzymatic α？ketothioester decarbonylation occurs in the assembly line of barbamide for skeleton editing. Journal of the American Chemical Society 2023, 145(9), 5017-5028.
7.?????? Ling Hu, Yi Qiao, Jingyu Liu, Chao Zheng, Xiaofeng Wang, Peng Sun, Yucheng Gu, Wen Liu*. Characterization of histidine functionalization and its timing in the biosynthesis of ribosomally synthesized and posttranslationally modified thioamitides. Journal of the American Chemical Society 2022, 144(10), 4431-4438.
8.?????? Bo Li, Xingyi Guan, Song Yang, Yike Zou, Wen Liu*, K. N. Houk*. Mechanism of the stereoselective catalysis of Diels？Alderase PyrE3 involved in pyrroindomycin biosynthesis. Journal of the American Chemical Society 2022, 144(11), 5099-5107.
9.?????? Sili Wang, Yiyuan Cheng, Xiaofeng Wang, Qian Yang, Wen Liu*. Tracing of acyl carrier protein-channeled mitomycin intermediates in Streptomyces caespitosus facilitates characterization of the biosynthetic steps for AHBA？GlcN formation and processing. Journal of the American Chemical Society 2022, 144(33), 14945-14956.
10.??? Zhi Lin#, Yufeng Xue#, Xiao-Wei Liang, Jian Wang, Shuangjun Lin, Jiang Tao, Shu-Li You*, Wen Liu*. Oxidative indole dearomatization for asymmetric furoindoline synthesis by a flavin-dependent monooxygenase involved in the biosynthesis of bicyclic thiopeptide thiostrepton. Angewandte Chemie-International Edition 2021, 60(15), 8401-8405.
11.??? Bo Pang#, Rijing Liao#, Zhijun Tang#, Shengjie Guo, Zhuhua Wu, Wen Liu*. Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2'-bipyridine formation. Nature Communications 2021, 12, 3124.
12.??? Botao Cheng#, Heng Guo#, Haoyang Wang, Qunfei Zhao, Wen Liu*. Dissection of the enzymatic process for forming a central imidazopiperidine heterocycle in the biosynthesis of a series c thiopeptide antibiotic. Journal of the American Chemical Society 2021, 143(34), 13790-13797.
13.??? Zhijun Tang#; Haoyu Tang#, Wanqiu Wang#, Yufeng Xue, Dandan Chen, Weihua Tang*, Wen Liu*. Biosynthesis of a new fusaoctaxin virulence factor in Fusarium graminearum relies on a distinct path to form a guanidinoacetyl starter unit priming nonribosomal octapeptidyl assembly. Journal of the American Chemical Society 2021, 143(47), 19719-19730.
14.??? Yanping Qiu#, Jingyu Liu#, Yuping Li, Yanqing Xue, Wen Liu*. Formation of an aminovinyl-cysteine residue in thioviridamides occurs through a path independent of known lanthionine synthetase activity. Cell Chemical Biology 2021, 28(5), 675-685.
15.??? Yanan Du#, Yanping Qu#, Xiang Meng, Junyin Feng, Jiang Tao, Wen Liu*. A heterotrimeric dehydrogenase complex functions with 2 distinct YcaO proteins to install 5 azole heterocycles into 35-membered sulfomycin thiopeptides. Journal of the American Chemical Society 2020, 142(18), 8454-8463.
16.??? Yike Zou, Song Yang, Jacob N. Sanders, Wei Li, Peiyuan Yu, Hongbo Wang, Zhijun Tang, Wen Liu*, K. N. Houk*. Computational investigation of the mechanism of Diels-Alderase PyrI4. Journal of the American Chemical Society 2020, 142(47), 20232-20239.
17.??? Daozhong Zhang, Fang Zhang, Wen Liu*. A KAS-III heterodimer in lipstatin biosynthesis nondecarboxylatively condenses C8 and C14 fatty acyl-CoA substrates by a variable mechanism during the establishment of a C22 aliphatic skeleton. Journal of the American Chemical Society 2019, 141(9), 3993-4001.
18.??? Daozhong Zhang, Zhijun Tang, Wen Liu*. Biosynthesis of lincosamide antibiotics: reactions associated with degradation and detoxification pathways play a constructive role. Accounts of Chemical Research 2018, 51(6), 1496-1506.
19.??? Qingfei Zheng#, Yukang Gong#, Yujiao Guo, Zhixiong Zhao, Zhuhua Wu, Zixuan Zhou, Dandan Chen, Lifeng Pan*, Wen Liu*. Structural insights into a flavin-dependent [4+2] cyclase that catalyzes trans-decalin formation in pyrroindomycin biosynthesis. Cell Chemical Biology 2018, 25(6), 718-727.
20.??? Jingjing Li, Yue Li, Guoqing Niu, Heng Guo, Yanping Qiu, Zhi Lin, Wen Liu*, Huarong Tan*. NosP-regulated nosiheptide production responds to both peptidyl and small-molecule ligands derived from the precursor peptide. Cell Chemical Biology 2018, 25(2), 143-153.
21.??? Guannan Zhong, Qunfei Zhao, Qinling Zhang, Wen Liu*. 4-Alkyl-L-(dehydro)proline biosynthesis in actinobacteria involves N-terminal nucleophile-hydrolase activity of γ-glutamyltranspeptidase homolog for C-C bond cleavage. Nature Communications 2017, 8, 16109.
22.???? Zhi Lin, Jia Ji, Shuaixiang Zhou, Fang Zhang, Jiequn Wu, Yinlong Guo, Wen Liu*. Processing 2-methyl-L-tryptophan through tandem transamination and selective oxygenation initiates indole ring expansion in the biosynthesis of thiostrepton. Journal of the American Chemical Society 2017, 139(35), 12105-12108.
23.???? Yanping Qiu#, Yanan Du#, Fang Zhang, Rijing Liao, Shuaixiang Zhou, Chao Peng, Yinlong Guo, Wen Liu*. Thiolation protein-based transfer of indolyl to a ribosomally synthesized polythiazolyl peptide intermediate during the biosynthesis of the side ring system of nosiheptide. Journal of the American Chemical Society 2017, 139(50), 18186-18189.
24.???? Zhi Lin, Qingli He, Wen Liu*. Bio-inspired engineering of thiopeptide antibiotics advances the expansion of molecular diversity and utility. Current Opinion in Biotechnology 2017, 48, 210-219.
25.???? Qingfei Zheng#, Shoufeng Wang#, Panpan Duan, Rijing Liao, Dandan Chen, Wen Liu*. An α/β-hydrolase fold protein in the biosynthesis of thiostrepton exhibits a dual activity for endopeptidyl hydrolysis and epoxide ring opening/macrocyclization. Proceedings of the National Academy of Sciences of the United States of America 2016, 113(50), 14318-14323.
26.???? Bo Pang#, Min Wang#, Wen Liu*. Cyclization of polyketides and non-ribosomal peptides on and off their assembly lines. Natural Product Reports 2016, 33(2), 162-173.
27.???? Qingfei Zheng#, Yujiao Guo#, Linlin Yang, Zhixiong Zhao, Zhuhua Wu, Hua Zhang, Jianping Liu, Xiaofang Cheng, Jiequn Wu, Huaiyu Yang, Hualiang Jiang, Lifeng Pan*, Wen Liu*. Enzyme-dependent [4+2] cycloaddition depends on lid-like interaction of the N-terminal sequence with the catalytic core in PyrI4. Cell Chemical Biology 2016, 23(3), 352-360.
28.???? Qingfei Zheng, Zhenhua Tian, Wen Liu*. Recent advances in understanding the enzymatic reactions of [4+2] cycloaddition and spiroketalization. Current Opinion in Chemical Biology 2016, 31, 95-102.
29.??? Qunfei Zhao#, Min Wang#, Dongxiao Xu, Qinglin Zhang, Wen Liu*. Metabolic coupling of two small-molecule thiols programs the biosynthesis of lincomycin A. Nature 2015, 518(7537), 115-119.
30.??? Zhenhua Tian#, Peng Sun#, Yan Yan#, Zhuhua Wu, Qingfei Zheng, Shuaixiang Zhou, Hua Zhang, Futao Yu, Xinying Jia, Dandan Chen, Attila Mándi, Tibor Kurtán, Wen Liu*. An enzymatic [4+2] cyclization cascade creates the pentacyclic core of pyrroindomycins. Nature Chemical Biology 2015, 11(4), 259-265.
31.??? Qingfei Zheng#, Qinglan Wang#, Shoufeng Wang#, Jiequn Wu, Qian Gao*, Wen Liu*. Thiopeptide antibiotics exhibit a dual mode of action against intracellular pathogens by affecting both host and microbe. Chemistry & Biology 2015, 22(8), 1002-1007.
32.??? Min Wang, Qunfei Zhao, Wen Liu*. The versatile low-molecular-weight thiols: Beyond cell protection.?Bioessays 2015, 37, 1262–1267.
33.??? Heng Guo, Jiang Wang, Yeming Li, Yi Yu, Qingfei Zheng, Jiequn Wu, Wen Liu*. Insight into bicyclic thiopeptide benefited from development of a uniform approach for molecular engineering and production improvement. Chemical Science 2014, 5, 240-246.
34.??? Yan Yan, Jing Chen, Lihan Zhang, Qingfei Zheng, Ying Han, Hua Zhang, Daozhong Zhang, Takayoshi Awakawa, Ikuro Abe, Wen Liu*. Multiplexing of combinatorial chemistry in antimycin biosynthesis: expansion of molecular diversity and utility. Angewandte Chemie-International Edition 2013, 52(47), 12308-12312.
35.???? Peng Sun, Qunfei Zhao, Futao Yu, Hua Zhang, Zhuhua Wu, Yinyan Wang, Yan Wang, Qinglin Zhang, Wen Liu*. Spiroketal formation and modification in avermectin biosynthesis involves a dual activity of AveC. Journal of the American Chemical Society 2013, 135(4), 1540-1548.
36.???? Qi Zhang, Bo Pang, Wei Ding, Wen Liu*. Aromatic polyketides produced by bacterial iterative type I polyketide synthases. ACS Catalysis 2013, 3(7), 1439-1447.
37.???? Qi Zhang, Wen Liu*. Biosynthesis of thiopeptide antibiotics and their pathway engineering. Natural Product Reports 2013, 30(2), 218-226.
38.???? Shoufeng Wang, Shuaixiang Zhou, Wen Liu*. Opportunities and challenges from current investigations into the biosynthetic logic of nosiheptide-represented thiopeptide antibiotics. Current Opinion in Chemical Biology 2013, 17(4), 626-634.
39.???? Qiongqiong Wu, Zhuhua Wu, Xudong Qu*, Wen Liu*. Insights into pyrroindomycin biosynthesis reveal a uniform paradigm for tetramate/tetronate formation. Journal of the American Chemical Society 2012, 134(42), 17342-17345.
40.??? Xudong Qu*, Bo Pang, Zhicong Zhang, Ming Chen, Zhuhua Wu, Qunfei Zhao, Qinglin Zhang, Yinyan Wang, Yun Liu, Wen Liu*. Caerulomycins and collismycins share a common paradigm for 2,2’-bipyridine biosynthesis via an unusual hybrid polyketide-peptide assembly logic. Journal of the American Chemical Society 2012, 134(22), 9038-9041.
41.??? Qi Zhang, Wilfred A. van der Donk, Wen Liu*. Radical-mediated enzymatic methylation: a tale of two SAMS. Accounts of Chemical Research 2012, 45(4), 555-564.
42.??? Lian Duan#, Shoufeng Wang#, Rijing Liao, Wen Liu*. Insights into quinaldic acid formation in thiostrepton biosynthesis facilitating fluorinated thiopeptide generation. Chemistry & Biology 2012, 19(4), 443-448.
43.??? Xudong Qu, Chun Lei, Wen Liu*. Transcriptome mining of active biosynthetic pathways and their associated products in Streptomyces flaveolus. Angewandte Chemie-International Edition 2011, 50(41), 9651-9654.
44.??? Qi Zhang, Yuxue Li, Dandan Chen, Yi Yu, Lian Duan, Ben Shen, Wen Liu*. Radical-mediated enzymatic carbon chain fragmentation-recombination. Nature Chemical Biology 2011, 7(3), 154-160.
45.??? Rijing Liao, Wen Liu*. Thiostrepton maturation involving a deesterification-amidation way to process the C-terminally methylated peptide backbone. Journal of the American Chemical Society 2011, 133(9), 2852-2855.
46.??? Yi Yu, Heng Guo, Qi Zhang, Lian Duan, Ying Ding, Rijing Liao, Chun Lei, Ben Shen, Wen Liu*. NosA catalyzing carboxyl-terminal amide formation in nosiheptide maturation via an enamine dealkylation on the serine-extended precursor peptide. Journal of the American Chemical Society 2010, 132(46), 16324-16326.
47.??? Wei Ding, Chun Lei, Qingli He, Qinglin Zhang, Yurong Bi, Wen Liu*. Insights into bacterial 6-methylsalicylic acid synthase and its engineering to orsellinic acid synthase for spirotetronate generation. Chemistry & Biology 2010, 17(5), 495-503.
48.??? Rijing Liao, Lian Duan, Chun Lei, Haixue Pan, Ying Ding, Qi Zhang, Daijie Chen, Ben Shen, Yi Yu*, Wen Liu*. Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications. Chemistry & Biology 2009, 16(2), 141-147.
49.??? Qunfei Zhao, Qingli He, Wei Ding, Mancheng Tang, Qianjin Kang, Yi Yu, Wei Deng, Qi Zhang, Jie Fang, Gongli Tang, Wen Liu*. Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis. Chemistry & Biology 2008, 15(7), 693-705.
50.??? Xin-Ying Jia, Zhen-Hua Tian, Lei Shao, Xu-Dong Qu, Qun-Fei Zhao, Jian Tang, Gong-Li Tang*, Wen Liu*. Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis. Chemistry & Biology 2006, 13(6), 575-585.
國(guó)家重點(diǎn)研發(fā)計(jì)劃“病原學(xué)與防疫技術(shù)體系研究”重點(diǎn)專項(xiàng)（2022YFC2303100），生物合成研究驅(qū)動(dòng)的新型微生物抗感染藥物創(chuàng)制，2022年12月-2025年11月，項(xiàng)目負(fù)責(zé)人；
國(guó)家自然科學(xué)基金重大項(xiàng)目（22193070），天然產(chǎn)物來(lái)源藥物的生物合成與分子創(chuàng)新，2022年01月-2026年12月，項(xiàng)目負(fù)責(zé)人；
國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目（32030002），富硫細(xì)菌環(huán)肽類代謝產(chǎn)物的翻譯后修飾、調(diào)控機(jī)制以及結(jié)構(gòu)與功能的多樣性研究，2021年01月-2025年12月，項(xiàng)目負(fù)責(zé)人；
國(guó)家自然科學(xué)基金應(yīng)急管理項(xiàng)目（21750004），大環(huán)天然產(chǎn)物的模板化生物合成及其活性與結(jié)構(gòu)導(dǎo)向的分子創(chuàng)新研究，2018年01月-2020年12月，項(xiàng)目負(fù)責(zé)人；
國(guó)家自然科學(xué)國(guó)際(地區(qū))合作與交流重點(diǎn)項(xiàng)目（21520102004），以多樣性為導(dǎo)向的天然產(chǎn)物生物合成研究，2016年01月-2020年12月，項(xiàng)目負(fù)責(zé)人；
國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目（31430005），以活性（抗腫瘤和抗感染）與作用機(jī)制研究為導(dǎo)向的硫肽類抗生素的生物合成，2015年01月-2019年12月，項(xiàng)目負(fù)責(zé)人；
國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目（20832009），天然產(chǎn)物獨(dú)特結(jié)構(gòu)單元的生物合成機(jī)制研究，2009年01月-2012年12月，項(xiàng)目負(fù)責(zé)人。
