
1994年畢業(yè)于南開大學(xué),獲環(huán)境化學(xué)學(xué)士學(xué)位,1999年獲中國(guó)科學(xué)院上海有機(jī)化學(xué)研究所生物有機(jī)化學(xué)博士學(xué)位,畢業(yè)后赴美國(guó)加州大學(xué)化學(xué)系進(jìn)行博士后研究,2001-2003年在美國(guó)威斯康辛大學(xué)藥學(xué)院任研究助理。2003年被聘為中國(guó)科學(xué)院上海有機(jī)化學(xué)研究所生命有機(jī)化學(xué)國(guó)家重點(diǎn)實(shí)驗(yàn)室研究員。
1) 天然產(chǎn)物生物合成研究:以微生物來(lái)源的結(jié)構(gòu)新奇、活性顯著的復(fù)雜天然產(chǎn)物為目標(biāo)分子,從基因和蛋白水平揭示自然界神奇的生物化學(xué)過(guò)程,理解其中蘊(yùn)涵的新型酶催化反應(yīng)和生理拮抗機(jī)制;在此基礎(chǔ)上一方面通過(guò)化學(xué)-生物相結(jié)合的策略來(lái)創(chuàng)造“非天然”天然產(chǎn)物,另一方面通過(guò)生物合成與生物信息相關(guān)聯(lián)的方法激活沉默基因簇,進(jìn)而發(fā)現(xiàn)新的天然產(chǎn)物。
2) 復(fù)雜天然產(chǎn)物類藥物的高效制備:以生物合成途徑為基礎(chǔ),采用微生物代謝工程或合成生物學(xué)的方法和策略致力于提高目標(biāo)化合物的產(chǎn)量,改變發(fā)酵產(chǎn)物的組份及產(chǎn)生新化合物;進(jìn)而通過(guò)與化學(xué)半合成或生物催化相結(jié)合發(fā)展高效的制備路線。
3) 抗腫瘤天然產(chǎn)物的化學(xué)生物學(xué)研究:利用優(yōu)化的噬菌體展示克隆或與生物合成相關(guān)聯(lián)的策略篩選、發(fā)現(xiàn)一些高活性天然產(chǎn)物的生物靶分子,進(jìn)而研究其生物活性的機(jī)理。
2004年獲得國(guó)家杰出青年基金
2005年入選上海市科技啟明星計(jì)劃
2008獲上海市啟明星跟蹤計(jì)劃資助
2014年入選上海市優(yōu)秀學(xué)術(shù)帶頭人,同年入選科技部中青年科技創(chuàng)新領(lǐng)軍人才
2015年入選國(guó)務(wù)院特殊津貼專家
2016年入選萬(wàn)人計(jì)劃-中青年科技創(chuàng)新領(lǐng)軍人才,同年入選上海市領(lǐng)軍人才。
1. Wang, F.; Zhang,W.-H.; Zhao, J.; Kang, W.-J.; Wang, S.; Yu, B.; Pan, H.-X.*; Tang, G.-L.* Characterization of miharamycin biosynthesis reveals a hybrid NRPS-PKS to synthesize high-carbon sugar from a complex nucleoside. J. Am. Chem. Soc. 2020, 142, 10.1021/jacs.0c01778.
2. Jin, W.-B.; Wu, S.; Xu, Y.-F.; Yuan, H.*; Tang, G.-L.* Recent advances in HemN-like radicalS-adenosyl-L-methionine enzyme-catalyzed reactions. Nat. Prod. Rep. 2020, 37, 17-28.
3. Ji, Z.-Y.; Nie, Q.-Y.; Yin, Y.; Zhang, M.; Pan, H.-X.; Hou, X.-F.*; Tang, G.-L.* Activation and characterization of cryptic gene cluster: Two series of aromatic polyketides biosynthesized by divergent pathways. Angew. Chem. Int. Ed. 2019, 58, 18046-18054.
4. Zhang, Y.; Wen, W.-H.; Pu, J.-Y.; Tang, M.-C.; Zhang, L.; Pen, C.; Xu, Y.; Tang, G.-L.* Extracellularly oxidative activation and inactivation of matured prodrug for cryptic self-resistance in naphthyridinomycin biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 2018, 115, 11232–11237.
5. Hou, X.-F.; Song, Y.-J.; Zhang, M.; Lan, W.; Meng, S.; Wang, C.; Pan, H.-X.; Cao, C.*; Tang, G.-L.* Enzymology of anthraquinone-g-pyrone ring formation in complex aromatic polyketide biosynthesis. Angew. Chem. Int. Ed. 2018, 57, 13475-13479.
6. Jin, W.-B.; Wu, S.; Jian, X.-H.; Yuan, H.*; Tang, G.-L.* A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis. Nat. Commun. 2018, 9, 2771.
7. Meng, S.; Han, W.; Zhao, J.; Jian, X.-H.; Pan, H.-X.*; Tang, G.-L.* A six-oxidase cascade for tandem C-H bond activation revealed by reconstitution of bicyclomycin biosynthesis. Angew. Chem. Int. Ed. 2018, 57, 719-723.
8. Yuan, H.; Zhang, J.; Cai, Y.; Wu, S.; Yang, K.; Stephen Chan, H. C.; Huang, W.; Jin, W.-B.; Li, Y.; Yin, Y.; Igarashi, Y.; Yuan, S.*; Zhou, J.*; Tang, G.-L.* GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection. Nat. Commun. 2017, 8, 1485.
9. Song, L.-Q.; Zhang, Y.-Y.; Pu, J.-Y.; Tang, M.-C.; Peng, C.; Tang, G.-L.* Catalysis of extracellular deamination by a FAD-linked oxidoreductase after prodrug maturation in the biosynthesis of saframycin A. Angew. Chem. Int. Ed. 2017, 56, 9116-9120.
10. Zhang, Z.; Gong, Y.-K.; Zhou, Q.; Hu, Y.; Ma, H.-M.; Chen, Y.-S.; Igarashi, Y.; Pan, L.*; Tang, G.-L.* Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade. Proc. Natl. Acad. Sci. U.S.A. 2017, 114, 1554–1559.
11. He, H.-Y.; Yuan, H.; Tang, M.-C.; Tang, G.-L.* An unusual dehydratase acting on glycerate and a ketoreducatse stereoselectively reducing α-ketone in polyketide starter unit biosynthesis. Angew. Chem. Int. Ed. 2014, 53, 11315-11319.
12. He, H.-Y.; Tang, M.-C.; Zhang, F.; Tang, G.-L.* Cis-Double bond formation by thioesterase and transfer by ketosynthase in FR901464 biosynthesis. J. Am. Chem. Soc. 2014, 136, 4488-4491.
13. Xu, H.; Huang, W.; He, Q.-L.; Zhao, Z.-X.; Zhang, F.; Wang, R.; Kang, J.; Tang, G.-L.* Self-resistance to antitumor antibiotic: a DNA glycosylase triggers the base excision repair system in yatakemycin biosynthesis. Angew. Chem. Int. Ed. 2012, 51, 10532-10536.
14. Huang, W.; Xu, H.; Li, Y.; Zhang, F.; Chen, X.-Y.; He, Q.-L.; Igarashi, Y.; Tang, G.-L.* Characterization of yatakemycin gene cluster revealing a radical SAM-dependent MT and highlighting spirocyclopropane biosynthesis. J. Am. Chem. Soc. 2012, 134, 8831-8840.
15. Peng, C.; Pu, J.-Y.; Song, L.-Q.; Jian, X.-H.; Tang, M.-C.; Tang, G.-L.* Hijacking a hydroxyethyl unitfrom a central metabolic ketose into a nonribosomal peptide assembly line. Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 8540-8545.
16. Zhang, F.; He, H.-Y.; Tang, M.-C.; Zhou, Q.; Tang, G.-L.* Cloning and elucidation of the FR901464 gene cluster revealing a complex AT-less PKS using glycerate as starter units. J. Am. Chem. Soc. 2011, 133, 2452-2462.

