2000.9-2004.6?北京大學(xué)化學(xué)與分子工程學(xué)院，理學(xué)學(xué)士，導(dǎo)師：楊震教授
2004.7-2009.11?The Scripps Research Institute，California，USA，Ph.D.，導(dǎo)師：Prof. K. C. Nicolaou
2010.1-2010.9?Institute of Chemical and Engineering Sciences，Singapore，research fellow，導(dǎo)師：Prof. K. C. Nicolaou
2010.9-至今?中國科學(xué)院上海有機(jī)化學(xué)研究所研究員
2019.11-至今 中國科學(xué)院上海有機(jī)化學(xué)研究所副所長(zhǎng)
2025.1-至今 中國科學(xué)院上海有機(jī)化學(xué)研究所黨委副書記
復(fù)雜天然產(chǎn)物的化學(xué)合成；天然產(chǎn)物的作用機(jī)制解析
2022??China Youth Science and Technology Award
2022??Chinese Chemical Society?Royal Society of Chemistry Young Chemist Award
2020??XPLORER Prize
2020??Thieme?IUPAC Prize in Synthetic Organic Chemistry
2019??Fellow, Royal Society of Chemistry
2017 ?Tetrahedron Young Investigator Award for Organic Synthesis
2016??Chinese?American Chemistry and Chemical Biology Professors Association Distinguished Faculty Award
2016??ChemComm Emerging Investigator Lectureship
2015??WuXi PharmaTech Life Science and Chemistry Award
2013??Chinese Chemical Society Wei-Shan Award for Natural Product Synthesis
2013??China Pharmaceutical Association?Servier Youth Medicinal Chemist Award
2007??Chinese Government Award for Outstanding Graduate Students Abroad
2007??Bristol?Myers Squibb Graduate Fellowship
1.?L.?Ren, Z.?Lu, D.?Wu, M.?Ma, A.?Li,* Total synthesis of paxdaphnine A and daphlongamine B via an aza-Prins cyclization strategy.?J. Am. Chem. Soc. DOI: 10.1021/jacs.4c04779.
2.?Y.?Fei, B.?Fan, Z.?Liu, M.?Ba, Z.?Cui, P.?Yang,* A.?Li,* Concise total synthesis of ambiguine P. J. Am. Chem. Soc. 2025, 147, 18391–18396.
3.?Y. Wu, S. Wang, Z. Guo, M. Sun, Z. Xu, Y. Du, F. Zhu, Y. Su, Z. Xu, Y. Xu, X. Gong, R. Fang, J. Hu, Y. Peng, Z. Ding, C. Liu, A. Li,* W. He,*?Hapalindole Q suppresses autophagosome?lysosome fusion by promoting YAP1 degradation via chaperon-mediated autophagy, Proc. Natl. Acad. Sci. U.S.A.?2024, 121, e2400809121.
4.?M.?Ba, F.?He, L.?Ren, W.?G. Whittingham, P.?Yang,?A.?Li,* Scalable total synthesis of acremolactone B, Angew. Chem. Int. Ed.?2024, 63, e202314800.
5.?Y. Peng, Y. Zhang, R. Fang, H. Jiang, G. Lan, Z. Xu, Y. Liu, Z. Nie, L. Ren, F. Wang, S.-D. Zhang, Y. Ma, P. Yang, H.-H. Ge, W.-D. Zhang,* C. Luo,* A. Li,* W. He,*?Target identification and mechanistic characterization of indole terpenoid mimics: proper spindle microtubule assembly is essential for Cdh1-mediated proteolysis of CENP-A, Adv. Sci.?2024, 11, 2305593.
6.?W.?Zhang, M.?Lu, L.?Ren, X.?Zhang, S.?Liu, M.?Ba, P.?Yang, A.?Li,* Total synthesis of four classes of Daphniphyllum?alkaloids, J. Am. Chem. Soc.?2023, 145, 26569–26579.
7.?B.-C. Yan, M. Zhou, J. Li, X.-N. Li, S.-J. He, J.-P. Zuo, H.-D. Sun, A. Li,* P.-T. Puno,* (–)-Isoscopariusin A, a naturally occurring immunosuppressive meroditerpenoid: structure elucidation and scalable chemical synthesis. Angew. Chem. Int. Ed.?2021,?60, 12859–12867.
8.?P. Yang, J. Li, L. Sun, M. Yao, X. Zhang, W.-L. Xiao, J.-H. Wang, P. Tian,* H.-D. Sun,* P.-T. Puno,*?A. Li,* Elucidation of the structure of pseudorubriflordilactone B by chemical synthesis. J. Am. Chem. Soc.?2020, 142, 13701–13708.
9.?S.?Zhou, K.?Xia, X.?Leng, A.?Li,*?Asymmetric total synthesis of arcutinidine, arcutinine, and arcutine. J. Am. Chem. Soc.?2019, 141, 13718–13723.
10.?X. Zhang, B. N. Kakde, R. Guo, S. Yadav, Y. Gu, A. Li,* Total synthesis of echitamine, akuammiline, rhazicine, and pseudoakuammigine. Angew. Chem. Int. Ed.?2019, 58, 6053–6058.
11.?Z. Lu, X. Zhang, Z. Guo, Y. Chen, T. Mu, A. Li,* Total synthesis of aplysiasecosterol A. J. Am. Chem. Soc.?2018, 140, 9211–9218.
12.?S. Zhou, R. Guo, P. Yang, A. Li,* Total synthesis of septedine and 7-deoxyseptedine. J. Am. Chem. Soc.?2018, 140, 9025–9029.
13.?W. Zhang, M. Ding, J. Li, Z. Guo, M. Lu, Y. Chen, L. Liu, Y.-H. Shen, A. Li,* Total synthesis of hybridaphniphylline B. J. Am. Chem. Soc.?2018, 140, 4227–4231.
14.?Y. Chen, W. Zhang, L. Ren, J. Li, A. Li,* Total syntheses of daphenylline, daphnipaxianine A, and himalenine D. Angew. Chem. Int. Ed.?2018, 57, 952–956.
15.?J. Li, W. Zhang, F. Zhang, Y. Chen, A. Li,* Total synthesis of daphniyunnine C (longeracinphyllin A). J. Am. Chem. Soc.?2017, 139, 14893?14896.
16.?Z. Zhang, J. Wang, J. Li, F. Yang, G. Liu, W. Tang, W. He, J.-J. Fu, Y.-H. Shen,* A. Li,* W.-D. Zhang,* Total synthesis and stereochemical assignment of delavatine A: Rh-catalyzed asymmetric hydrogenation of indene-type tetrasubstituted olefins and kinetic resolution through Pd-catalyzed triflamide-directed C?H olefination. J. Am. Chem. Soc.?2017, 139, 5558–5567.
17.?H. Li, Q. Chen, Z. Lu, A. Li,*?Total syntheses of aflavazole and 14-hydroxyaflavinine. J. Am. Chem. Soc.?2016, 138, 15555–15558.
18.?P. Yang, M. Yao, J. Li, Y. Li, A. Li,* Total synthesis of rubriflordilactone B. Angew. Chem. Int. Ed.?2016, 55,?6964–6968.
19.?Y. Li, S. Zhu, J. Li, A.?Li,* Asymmetric total syntheses of aspidodasycarpine, lonicerine, and the proposed structure of lanciferine. J. Am. Chem. Soc.?2016, 138, 3982–3985.
20.?M. Yang, X. Yang, H. Sun, A. Li,* Total synthesis of ileabethoxazole, pseudopteroxazole, and seco-pseudopteroxazole.?Angew. Chem. Int. Ed. 2016, 55, 2851–2855.
21.?Z. Lu, H. Li, M. Bian, A. Li,* Total synthesis of epoxyeujindole A. J. Am. Chem. Soc.?2015, 137, 13764–13767.
22.?S. Zhou, H. Chen, Y. Luo, W. Zhang, A. Li,*?Asymmetric total synthesis of mycoleptodiscin A. Angew. Chem. Int. Ed.?2015, 54, 6878–6882.
23.?M. Yang, J. Li, A. Li,* Total synthesis of clostrubin. Nat. Commun.?2015, 6, 6445.
24.?Z. Meng, H. Yu, L. Li, W. Tao, H. Chen, M. Wan, D. J. Edmonds, J. Zhong, A. Li,* Total synthesis and antiviral activity of indolosesquiterpenoids from the xiamycin and oridamycin families. Nat. Commun.?2015, 6, 6096.
25.?J. Li, P. Yang, M. Yao, J. Deng, A. Li,* Total synthesis of rubriflordilactone A. J. Am. Chem. Soc.?2014, 136, 16477–16480.
26.?Z. Lu, M. Yang, P. Chen, X. Xiong, A. Li,* Total synthesis of hapalindole-type natural products. Angew. Chem. Int. Ed.?2014, 53, 13840–13844.
27.?Y. Sun, P. Chen, D. Zhang, M. Baunach, C. Hertweck, A. Li,* Bioinspired total synthesis of sespenine. Angew. Chem. Int. Ed.?2014, 53, 9012–9016.
28.?J. Deng, S. Zhou, W. Zhang, J. Li, R. Li, A. Li,* Total synthesis of taiwaniadducts B, C, and D.?J. Am. Chem. Soc. 2014,?136, 8185–8188.
29.?Y. Sun, R. Li, W. Zhang, A. Li,* Total synthesis of indotertine A and drimentines A, F, and G. Angew. Chem. Int. Ed.?2013, 52, 9201–9204.
30.?Z. Lu, Y. Li, J. Deng, A. Li,* Total synthesis of the Daphniphyllum?alkaloid daphenylline. Nat. Chem.?2013, 5, 679–684.
31.?M. Bian, Z. Wang, X. Xiong, Y. Sun, C. Matera, K. C. Nicolaou,* A. Li,* Total syntheses of anominine and tubingensin A. J. Am. Chem. Soc.?2012, 134, 8078–8081.
32.?J. Deng, B. Zhu, Z. Lu, H. Yu, A. Li,* Total synthesis of (–)-fusarisetin A and reassignment of the absolute configuration of its natural counterpart. J. Am. Chem. Soc. 2012, 134, 920–923.
