
1990年畢業(yè)于陜西師范大學化學系,1990-1996年在中國科學院蘭州化學物理研究所攻讀分析化學碩士和博士研究生,獲理學博士學位。1999年至2010年在比利時Leuven大學藥學院做博士后研究,2000年10月至2003年9月在德國Tubingen大學有機化學研究所從事博士后研究。2003年入選中國科學院人才計劃任中國科學院上海有機化學研究所研究員,課題組長和博士生導師。2009年至2015年任上海有機所分析化學研究室主任。2015年至今生命有機化學國家重點實驗室。中國化學會色譜分析專業(yè)委員會委員,《色譜》期刊副主編,《有機化學》,《儀器分析與技術》,《separation》編委。
發(fā)展新的分析方法和技術用于抗腫瘤藥物的高效篩選,在細胞水平獲得活性、選擇性和作用靶標譜;通過發(fā)展新的基于質譜的多組學分析方法,在研發(fā)早期準確評估藥物的療效并預測副作用,降低新藥研發(fā)失敗的風險。
1. 基于色譜-質譜分析的高效率的藥物篩選技術
2. 多組學集成解析藥物作用靶標和機制
3. 組蛋白和DNA表觀遺傳化學修飾的小分子調控
1. 中國科學院人才計劃資助
2. 2017年中國分析測試協(xié)會科學技術一等獎
3. 2019年第21屆中國發(fā)明專利優(yōu)秀獎
1. Y. XU, M. M Zheng, L. Gong, G.Z. Liu, S. S. Qian, Y. Han, J.W. Kang, Comprehensive profiling of rapamycin interacting proteins with multiple mass spectrometry-based omics techniques, Anal Chem, 2023, in press.
2. D. Qiu, G. Liu, F. Li, J. Kang, Determination of 5-methyldeoxycytosine and oxidized derivatives by nano-liquid chromatography with zwitterionic monolithic capillary column, J Chromatogr A 1693 (2023) 463895.
3. S. S. Qian, Y. Han, Y. Zhang, Y. Du, J. Li, X. Yang, J. Kang, Discovery of AHCY as an off-target of doxorubicin by integrative analysis of photoaffinity labeling chemoproteomics and untargeted metabolomics, Anal Chem 94(49) (2022) 17121-17130.
4. C. Lou, X. Ye, G. Chen, J. Zhu, J. Kang, Screening inhibitors for blocking UHRF1-methylated DNA interaction with capillary electrophoresis, J Chromatogr A 1636 (2021) 461790.
5. G. Liu, T. Fu, Y. Han, S. Hu, X. Zhang, M. Zheng, P. Hao, L. Pan, J. Kang, probing protein–protein interactions with label-free mass spectrometry quantification in combination with affinity purification by spin-tip affinity column, Anal Chem 92(2020) 3913-3922.
6. Y. Zhang, C. Lou, Y. Xu, J. Li, S. Qian, F. Li, J. Kang, screening of inhibitors against histone demethylation jumonji domain-containing protein 3 by capillary electrophoresis, J Chromatogr A (2019) 460625.
7. M. Xu, M. Zheng, G. Liu, M. Zhang, J. Kang, screening of break point cluster region belson tyrosine kinase inhibitors by capillary electrophoresis, J Chromatogr A, 1537 (2018) 128-134.
8. M. Xu, C. Liu, M. Zhou, Q. Li, R. Wang, J. Kang, screening of small-molecule inhibitors of protein–protein interaction with capillary electrophoresis frontal analysis, Anal Chem, 88 (2016) 8050-8057.
9. F. Li, Y. Zhang, D. Qiu, J. Kang, screening of epidermal growth factor receptor inhibitors in natural products by capillary electrophoresis combined with high performance liquid chromatography–tandem mass spectrometry, J Chromatogr A, 1400 (2015) 117-123.
10. Q. Zhang, X. Chen, Z. Zhu, X. Zhan, Y. Wu, L. Song, J. Kang, structural analysis of low molecular weight heparin by ultraperformance size exclusion chromatography/time of flight mass spectrometry and capillary zone electrophoresis, Anal Chem, 85 (2013) 1819-1827.

