
陳以昀博士,現(xiàn)任中國(guó)科學(xué)院上海有機(jī)化學(xué)研究所研究員、生命過(guò)程小分子調(diào)控全國(guó)重點(diǎn)實(shí)驗(yàn)室課題組長(zhǎng),兼任上??萍即髮W(xué)及國(guó)科大杭州高等研究院教授。陳以昀博士本科畢業(yè)于北京大學(xué),后于普林斯頓大學(xué)獲得博士學(xué)位,隨后在哈佛大學(xué)與霍華德休斯醫(yī)學(xué)研究所完成博士后研究。自獨(dú)立開(kāi)展研究以來(lái),陳以昀博士一直致力于生物相容性光化學(xué)方向的探索,專(zhuān)注于發(fā)展新型有機(jī)光化學(xué)反應(yīng)技術(shù)并推動(dòng)其在生物體系中的應(yīng)用,取得了多項(xiàng)具有重要意義的研究成果,主要包括:1)發(fā)現(xiàn)有機(jī)硼酸鹽類(lèi)化合物的光誘導(dǎo)遷移反應(yīng);2)首次將環(huán)狀高價(jià)碘(III)試劑BI應(yīng)用于光催化反應(yīng),系統(tǒng)闡明烷氧自由基在α位點(diǎn)的反應(yīng)特性,并首次實(shí)現(xiàn)甲酰自由基的生成;3)開(kāi)發(fā)出一系列基于氧自由基與疊氮化合物的生物正交光催化新方法,成功應(yīng)用于前藥激活以及蛋白質(zhì)與脂質(zhì)的鄰近標(biāo)記。這些系統(tǒng)性工作為藥物研發(fā)、疾病診斷與治療等領(lǐng)域提供了創(chuàng)新研究工具和潛在應(yīng)用途徑,具有顯著的學(xué)術(shù)價(jià)值與轉(zhuǎn)化前景。
生物相容光化學(xué):有機(jī)光化學(xué),光化學(xué)生物學(xué)
2023-至今 上海市徐匯區(qū)第六屆中青年知識(shí)分子聯(lián)誼會(huì)理事
2022-至今 上海市徐匯區(qū)政協(xié)委員
2022-至今 上??破罩驹刚邊f(xié)會(huì),院士專(zhuān)家指導(dǎo)團(tuán)青年科學(xué)家
2021-至今 中國(guó)感光學(xué)會(huì)光化學(xué)和光生物專(zhuān)業(yè)委員會(huì),專(zhuān)委會(huì)委員
2020-至今 Organic Chemistry Frontiers (RSC),顧問(wèn)編委
2020-至今 中國(guó)神經(jīng)科學(xué)學(xué)會(huì)“離子通道與受體”專(zhuān)業(yè)委員會(huì),分會(huì)常務(wù)委員
2019-至今 歐盟研究委員會(huì),外部評(píng)審專(zhuān)家
2018-至今 中國(guó)化學(xué)會(huì)光化學(xué)專(zhuān)業(yè)委員會(huì),分會(huì)委員
2016-2021 ChemPhotoChem (Wiley),創(chuàng)刊編委
上海市東方英才計(jì)劃領(lǐng)軍項(xiàng)目,中國(guó),2024
中國(guó)科學(xué)院大學(xué)優(yōu)秀授課教師,中國(guó),2023
藥明康德生命化學(xué)研究獎(jiǎng),中國(guó),2021
上海市科技系統(tǒng)青年五四獎(jiǎng)?wù)?,中?guó),2018
Thieme化學(xué)期刊獎(jiǎng),德國(guó),2018
中國(guó)光化學(xué)優(yōu)秀青年科學(xué)家獎(jiǎng),中國(guó),2017
普林斯頓大學(xué)百時(shí)美施貴寶研究生合成化學(xué)獎(jiǎng),美國(guó),2005
1.?Wang, Y.1; Bao, P.1; Dong, X.1; Lan, Y.*; Chen, Y.*??Thiophenol-Catalyzed Radical Hydroformylation of Unactivated Sterically Hindered Alkenes. J.?Am. Chem. Soc. 2025,?https://doi.org/10.1021/jacs.5c07415.
2.?Chen, X.1; He, R.1; Xiong, H.; Wang. R.; Yin, Y.; Chen, Y.*; Zhu, Z.* ?Quantitative Profiling of Lipid Transport?between Organelles Enabled by Subcellular Photocatalytic Labeling.?Nat. Chem. 2025,?https://doi.org/10.1038/s41557-025-01886-w.?
3.?Zou, P.1; Fu, D.1; Wang, H.1; Sun, R.; Lan, Y.*; Chen, Y.*??Photochemical 1,3-Boronate Rearrangement Enables Three-Component N-Alkylation for α-Tertiary Hydroxybenzylamine Synthesis.?Nat. Commun.?2024,?15, 10234.?
4.?Dong, X.1; Shao, Y.1; Liu, Z.;?Huang, X.; ?Xue, X.*; Chen, Y.*??Radical 6-Endo Addition Enables Pyridine Synthesis under Metal-Free Conditions. Angew. Chem., Int. Ed.?2024,?63, e202410297.?
5.?Zeng, K.1; Jiao, Z.1; Jiang, Q.; He, R.; Zhang, Y.; Li, W.*; Xu, T.*; Chen, Y.*??Genetically Encoded Photocatalysis Enables Spatially Restricted Optochemical Modulation of Neurons in Live Mice. ?ACS Cent. Sci.?2024, 10, 1, 163–175. ??
6.?Hao, K.1; Li, D.1; Fu, D.; Zou, P.; Xie, S.; Lan, Y.*; Chen, Y.*??Metal-Free 1,3-Boronate Rearrangement to Ketones Driven by Visible Light.?Angew. Chem., Int. Ed.?2024, 63, e202316481.
7.?Liu, D.1; Yang, K.1; Fang, D.1; Li, S.; Lan, Y.*; Chen, Y.*?Formyl Radical Generation from α-Chloro N-Methoxyphthalimides Enables Selective Aldehyde Synthesis. Angew. Chem., Int. Ed.?2023, 62, e202213686.
8.?Zhang, Y.1; Han, L.1; Tian, X.; Peng, C.; Chen, Y.*?Ligand-Directed Caging Enables the Control of Endogenous DNA Alkyltransferase Activity with Light inside Live Cells. Angew. Chem., Int. Ed.?2022, 61, e202115472.??
9.?Wang, H.1; Zhang, Y.1; Zeng, K.1; Qiang, J.1; Cao, Y.; Li, Y.; Fang, Y.; Zhang, Y.*; Chen, Y.*?Selective Mitochondrial Protein Labeling Enabled by Biocompatible Photocatalytic Reactions inside Live Cells. JACS Au?2021, 1, 1066?1075.??
10.?Xie, S.; Li, D.; Huang, H.; Zhang, F.; Chen, Y.*?Intermolecular Radical Addition to Ketoacids Enabled by Boron Activation. J.?Am. Chem. Soc. 2019, 141,?16237?16242.
11.?Wang, H; Li, W.; Zeng, K.; Wu, Y.; Zhang, Y.; Xu, T.*; Chen, Y.*?Photocatalysis Enables Visible Light Uncaging of Bioactive Molecules in Live Cells.?Angew. Chem., Int. Ed.?2019, 58, 561?565. ??
12.?Zhang, J.; Li, Y.; Xu, R.; Chen, Y.*??Donor-Acceptor Complex Enables Alkoxyl Radical Generation for Metal-Free C(sp3)-C(sp3) Cleavage and Allylation/Alkenylation. Angew. Chem., Int. Ed. 2017, 56, 12619?12623.
13.?Jia, K.; Pan, Y.; Chen, Y.*??Selective Carbonyl-C(sp3) Bond Cleavage to Construct Ynamides, Ynoates, and Ynones by Photoredox Catalysis. Angew. Chem., Int. Ed.?2017, 56, 2478–2481.
14.?Qi, L.; Chen, Y.*?Polarity-Reversed Allylations of Aldehydes, Ketones, and Imines Enabled by Hantzsch Ester in Photoredox Catalysis.?Angew. Chem., Int. Ed.?2016, 55, 13312?13315.
15.?Jia, K.; Zhang, F.; Huang, H.; Chen, Y.*?Visible-Light-Induced Alkoxyl Radical Generation Enables Selective C(sp3)-C(sp3) Bond Cleavage and Functionalizations.?J. Am. Chem. Soc.?2016, 138, 1514?1517.
16.?Zhang, J.; Li, Y.; Zhang, F.; Hu, C.; Chen, Y.*?Generation of Alkoxyl Radicals by Photoredox Catalysis Enables Selective C(sp3)-H Functionalization under Mild Reaction Conditions.?Angew. Chem., Int. Ed.?2016, 55, 1872?1875.
17.?Huang, H.1; Zhang, G.1; Chen, Y.* Dual Hypervalent Iodine(III) Reagents and Photoredox Catalysis Enable Decarboxylative Ynonylation under Mild Conditions. Angew. Chem., Int. Ed. 2015, 54, 7872?7876.
18.?Huang, H.; Jia, K.; Chen, Y.*?Hypervalent Iodine Reagents Enable Chemoselective Deboronative/Decarboxylative Alkenylation by Photoredox Catalysis. Angew. Chem., Int. Ed.?2015, 54, 1881?1884.
19.?Huang, H.; Zhang, G.; Gong, L.; Zhang, S.; Chen, Y.*, Visible-Light-Induced Chemoselective Deboronative Alkynylation under Biomolecule-Compatible Conditions. J. Am. Chem. Soc.?2014, 136, 2280?2283.
20.?Dumelin, C.; Chen, Y.; Leconte, A. M.; Chen, Y. G.; Liu, D. R.*, Discovery and Biological Characterization of?Geranylated RNA in Bacteria. Nat. Chem. Bio.?2012, 8, 913?919.
21.?Chen, Y.; Kamlet, A. S.; Steinman, J. B.; Liu, D. R.*, A Biomolecule-Compatible Visible-Light-Induced Azide Reduction from a DNA-Encoded Reaction-Discovery System.?Nature Chem.?2011, 3, 146?153.
22.Chen, Y.; Ho, D. M.; Lee, C.*, Ruthenium-Catalyzed Hydrative Cyclization of 1,5-Enynes. J. Am. Chem. Soc.?2005,?127,?12184?12185.
國(guó)家自然科學(xué)基金委員會(huì)重點(diǎn)項(xiàng)目
上海市優(yōu)秀學(xué)術(shù)帶頭人計(jì)劃
中國(guó)科學(xué)院創(chuàng)新交叉團(tuán)隊(duì)
國(guó)家自然科學(xué)基金委員會(huì)優(yōu)秀青年科學(xué)基金項(xiàng)目
上海市浦江人才計(jì)劃項(xiàng)目

