2001年9月~ 2005年7月，復(fù)旦大學(xué)化學(xué)系，獲理學(xué)學(xué)士學(xué)位。
2005年9月~ 2010年6月，香港科技大學(xué)生物化學(xué)系，獲哲學(xué)博士學(xué)位。
2010年8月~ 2011年2月，香港科技大學(xué)生命科學(xué)部，助理研究員。
2011年3月~ 2012年8月，香港科技大學(xué)生命科學(xué)部，研究助理教授。
2013年1月~ 2013年4月，美國哈佛大學(xué)醫(yī)學(xué)院，訪問學(xué)者。
2012年8月~至今，中國科學(xué)院上海有機(jī)化學(xué)研究所，研究員、課題組長。
1.以人類疾病為導(dǎo)向，綜合利用結(jié)構(gòu)生物學(xué)、化學(xué)生物學(xué)、生物化學(xué)等多手段的交叉學(xué)科研究，具體包括：研究與癌癥、神經(jīng)退行性疾病相關(guān)的細(xì)胞自噬通路，揭示相關(guān)未知的分子機(jī)制和致病機(jī)理；研究與疾病相關(guān)的重要E3泛素酶的結(jié)構(gòu)與作用機(jī)制，并研發(fā)相關(guān)的小分子調(diào)節(jié)劑和靶向降解技術(shù)，用于后續(xù)相關(guān)的化學(xué)生物學(xué)和潛在的疾病治療研究。
2.活性小分子的化學(xué)生物學(xué)研究，具體包括：天然活性小分子與靶點(diǎn)蛋白相互作用的機(jī)制研究；重要生物合成酶與小分子的互作機(jī)制以及相關(guān)的催化反應(yīng)機(jī)理研究。
上海市生物物理學(xué)會第十二屆理事會理事
中國生物物理學(xué)會生物磁共振專業(yè)委員會秘書長
Autophagy Reports雜志編委
Cells雜志編委
Frontiers in Molecular Biosciences雜志評審編委
《生物化學(xué)和生物物理進(jìn)展》雜志青年編委
2024：上海市東方英才領(lǐng)軍項目
2021：中國科學(xué)院朱李月華優(yōu)秀教師獎
2020：上海市青年五四獎?wù)聜€人；上海市優(yōu)秀學(xué)術(shù)帶頭人。
2019：上海市科技系統(tǒng)青年五四獎?wù)?/span>
2018：基金委優(yōu)秀青年科學(xué)基金
2017：中國化學(xué)會青年化學(xué)獎
2013：國家人才計劃青年項目；上海市科技啟明星計劃。
1.?Feng J, Wang S, Yang X, Tian T, Huang W, Teng X, Pan HX, Sun A, Pu J*, Pan L*, Tang GL* "S-Methyl Thioester Formation Uncovers Early Biosynthetic Steps of Yatakemycin" Angew. Chem. Int. Ed.?2026, 65(15):e22109..
2.?Hu L, Li M, Sang Y, Zhao C, Huang J, Huang W, Xue Y, Liu L, Gu Y, Ma P*, Xue X*, Pan L*, Liu W* "Pseudokinases Catalyze Peptide Cyclization through Thioether Crosslinking" Nature Chemistry. 2026, 18, 152-163.
3.?Gong X, Zhou Y, Wang Y, Tang Y, Liu H, Zhou X, Zhang Y, Guo H, Guo Z, Pan L* "Molecular bases of the interactions of ATG16L1 with FIP200 and ATG8 family proteins" Nature Communications. 2025, 16(1):9035.
4.?Wang Y, Zhou X, Wang Y, Gong X,?Tang Y, Zhang Y,?Liu H, Huang Y, Lin Z, Liu J*, Pan L* "STK4 inhibits the E3 activity of HOIP by phosphorylating its allosteric ubiquitin-binding site" Cell Discovery. 2025,?11(1):75.
5.?Liu H, Shen L, Gong X, Zhang Y, Zhou X, Huang Y, Zhou Y, Guo Z, Guo H, Wang S, Pan L* "Mechanistic insights into the iron-sulfur cluster-dependent interaction of autophagy receptor NCOA4 with the E3 ligase HERC2" PNAS. 2025, 122(30):e2510269122.
6.?Zhou X, Zhang H, Wang Y, Wang D, Lin Z, Zhang Y, Tang Y, Liu J, Yao Y*, Zhang Y*, Pan L* "Shigella?effector IpaH1.4 subverts host E3 ligase RNF213 to evade antibacterial immunity" Nature Communications. 2025, 16(1):3099.
7.?Tang Y, Han Y, Li Y, Gong X, Guo Z, Zhang Y, Liu H, Zhou X, Xu D, Zhang Y*, Pan L* "Mechanistic insights into the GEF activity of the human MON1A/CCZ1/C18orf8 complex" Protein & Cell. 2025, 16(8):739-744.
8.?Zhang Y, Sun Y, Shi J, Xu P, Wang Y, Liu J, Gong X, Wang Y, Tang Y, Liu H, Zhou X, Lin Z, Baba O, Morita T, Yu B*, Pan L* "Decoding the molecular mechanism of selective autophagy of glycogen mediated by autophagy receptor STBD1" PNAS. 2024, 121(37):e2402817121.
9.?Zhang M, Wang Y, Gong X, Wang Y, Zhang Y, Tang Y, Zhou X, Liu H, Huang Y, Zhang J, Pan L* "Mechanistic insights into the interactions of TAX1BP1 with RB1CC1 and mammalian ATG8 family proteins" PNAS. 2024, 121(11):e2315550121.
10.?Xu X, Wang Y, Zhang Y, Wang Y, Yin Y, Peng C, Gong X, Li M, Zhang Y, Zhang M, Tang Y, Zhou X, Liu H, Pan L* "Mechanistic insights into the enzymatic activity of E3 ligase HOIL-1L and its regulation by the linear ubiquitin chain-binding" Science Advances.?2023, 9(41):eadi4599.
11.?Zhang T, Xu D, Trefts E, Lv M, Liu J, Liu M, Chu C, Wang M, Wang H, Meng H, Liu H, Zhuang Y, Xie X, Dang F, Jiang C, Dai X, Lee Y, Inuzuka H, Erickson E, Hillis A, Dibble C, Miao J, Asara J, Szabo G, Sicinski P, Pan L*, Shaw R*, Yuan J*, Wei W* "Metabolic Orchestration of Necroptosis and Inflammation through AMPK-Mediated Phosphorylation of RIPK1" Science. 2023, 380, 1372-1380.
12.?Feng?K, Zhang?Y, Zhang?M, Yang?Y, Liu?J, Pan L*, Zeng Y*?"A flavin-monooxygenase catalyzing oxepinone formation and the complete biosynthesis of vibralactone" Nature Communications. 2023, 14(1):3436.
13.?Gong X, Pan L* "ATG16L1 is equipped with two distinct WIPI2-binding sites to drive autophagy" Autophagy. 2024, 20(4):938-940.
14.?Gong X, Wang Y, Tang Y, Liu J, Wang Y, Xu X, Zhang M, Li M, Zhang Y, Pan L* "ATG16L1 adopts a dual-binding-site mode to interact with WIPI2b in autophagy"?Science Advances. 2023,?9(9):eadf0824.
15.?Wang H, Zou Y, Li M, Tang Z, Wang J, Tian Z, Strassner N, Yang Q, Zheng Q, Guo Y, Liu W*, Pan L*, Houk K* "A cyclase that catalyses competing 2+2 and 4+2 cycloadditions" Nature Chemistry. 2023, 15, 177-184.
16.?Liu J#*, Wang Y#, Wang D#, Wang Y, Xu X, Zhang Y, Li Y, Zhang M, Gong X, Tang Y, Li M, Pan L* "Mechanistic insights into the subversion of the linear ubiquitin chain assembly complex by the E3 ligase IpaH1.4 of Shigella flexneri" PNAS. 2022, 119(12):e2116776119.
17.?Fu T, Zhang M, Zhou Z, Wu P, Peng C, Wang Y, Gong X, Li Y, Wang Y, Xu X, Li M, Shen L, Pan L* "Structural and biochemical advances on the recruitment of the autophagy-initiating ULK and TBK1 complexes by autophagy receptor NDP52"?Science Advances.?2021, 7(33):eabi6582.
18.?Shan H, Liu J, Shen J, Dai J, Xu G, Lu K, Han C, Wang Y, Xu X, Tong Y, Xiang H, Ai Z, Zhuang G, Hu J, Zhang Z*, Li Y*, Pan L*, Tan L*?"Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2"?Cell Chemical Biology. 2021, 28, 855-865.
19.?Zhou Z, Liu J, Fu T, Wu P, Peng C, Gong X, Wang Y, Zhang?M, Li Y, Wang?Y, Xu?X, Li M, Pan L* "Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation"?Nature Communications. 2021, 12(1):1570.?(Recommended by Faculty Opinions)
20.?Li Y, Cheng Y, Li M, Wang Y, Fu T, Zhou Z,?Wang Y,?Gong X, Xu X, Liu J, Pan L* "Decoding three distinct states of the Syntaxin17 SNARE motif in mediating the autophagosome-lysosome fusion"?PNAS. 2020,?117, 21391-21402.?(Recommended by Faculty Opinions)
21.?Hu S, Guo Y, Wang?Y, Li Y, Fu T, Zhou Z, Wang Y, Liu J, Pan L* "Structure of Myosin VI/Tom1 complex reveals a cargo recognition mode of Myosin VI for tethering"?Nature Communications. 2019, 10(1):3459.
22.?Pan L*, Liu J, Li Y,?"Structural Basis of Autophagy Regulatory Proteins"?Advances in Experimental Medicine and Biology. 2019, 1206:287-326.?(invited Book chapter review)
23.?Fu?T, Liu?J, Wang?Y, Xie?X, Hu?S, Pan L* "Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1"?PNAS.?2018, 115, E11651-E11660.
24.?Xu D, Jin T, Zhu H, Chen H, Ofengeim?D, Zuo C, Mifflin?L, Pan L, Amin?P, Li W, Shan B, Naito?M, Meng?H, Y?Li, Pan H, Aron L, Adiconis X, Levin J, Yankner B, Yuan J.* "TBK1 suppresses RIPK1-driven apoptosis and inflammation during development and in aging" Cell. 2018, 174, 1477-1491.
25.?Li F, Xu D, Wang Y, Zhou Z, Liu J, Hu S, Gong Y, Yuan J, Pan L* "Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation" Autophagy. 2018, 14, 66-79.
26.?Liu J, Wang Y, Gong Y,?Fu T,?Hu S, Zhou Z, Pan L* "Structural Insights into SHARPIN-mediated Activation of HOIP for the Linear Ubiquitin Chain Assembly" Cell Reports. 2017, 21(1):27-36.
27.?Xu?D, Liu?J, Fu?T, Shan?B, Qian L, Pan?L*, Yuan?J* "USP25 Regulates Wnt Signaling by Controlling the Stability of Tankyrases"?Genes. Dev. 2017, 31, 1024-1035.
28.?Zhang Z, Gong YK, Zhou Q, Hu Y, Ma HM, Chen YS, Igarashi Y, Pan L*,?Tang G* "Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade"?PNAS. 2017, 114,?1554-1559.
29.?Li F, Xie X,?Wang Y, Liu J,?Cheng X, Guo Y, Gong Y, Hu S, Pan L* "Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins"?Nature Communications.?2016, 7:12708.
30.?Cheng?X, Wang?Y, Gong?Y, Li?F, Guo?Y, Hu?S, Liu?J, Pan?L*?"Structural Basis of FYCO1 and MAP1LC3A Interaction Reveals a Novel Binding Mode for Atg8 Family Proteins"?Autophagy. 2016, 12, 1330-1339.
31.?Zheng Q, Guo Y, Yang L, Zhao Z, Wu Z, Zhang H, Liu J, Cheng X, Wu J, Yang H, Jiang H, Pan L*, and Liu W*?"Enzyme-Dependent [4+2] Cycloaddition Depends on Lid-like Interaction of the N-Terminal Sequence with the Catalytic Core in PyrI4"?Cell Chemical Biology.?2016, 23, 352-360.
32.?Xie?X, Li?F, Wang Y, Wang?Y, Lin?Z, Cheng?X, Liu?J, Chen?C,?Pan?L*?"Molecular Basis of Ubiquitin Recognition by Autophagy Receptor CALCOCO2"?Autophagy.?2015, 10, 1775-1789.
33.?Pan L, Zhang M.* "Structures of Usher Syndrome 1 Proteins and Their Complexes" Physiology,?2012, 27, 25-42. (invited review, cover story)
34.?Wu L#, Pan L#, Wei Z, Zhang M* "Structure of MyTH4-FERM Domains in Myosin VIIa Tail Bound to Cargo" Science.?2011,?331,?757-760.?(#:co-first authors,?highlighted by Faculty of 1000,?F1000 Cell Biology and F1000 Genomics & Genetics)
35.?Yan J#, Pan L#, Chen X, Wu L, Zhang M*?"The Structure of the Harmonin/Sans Complex Reveals an Unexpected Interaction Mode of the Two Usher Syndrome Proteins" PNAS. 2010,107,?4040-4045.?(#: co-first authors)
36.?Pan L#, Yan J#, Wu L, Zhang M*?"Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23" PNAS. 2009, 106,?5575-5580. (#: co-first authors)
37.?Chen J#, Pan L#, Wei Z, Zhao Y, Zhang M* "Domain Swapped Dimerization of ZO-1 PDZ2 Generates Specific and Regulatory Connexin43 Binding Sites" EMBO J, 2008, 27,?2113-2123. (#: co-first authors)
38.?Pan L#, Wu H#, Shen C#, Shi Y, Jin W, Xia J, Zhang M*?"Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes" EMBO J,?2007,?26, 4576-4587. (#: co-first authors)
