
2001年9月~ 2005年7月,四川大學化學學院,獲理學學士學位。
2005年9月~ 2010年6月,中國科學技術(shù)大學生命科學學院,獲哲學博士學位。
2010年7月~ 2016年1月,美國Scripps研究所,助理研究員。
2016年1月~至今,中國科學院上海有機化學研究所研究員。
結(jié)構(gòu)指導的靶向自噬反應主要調(diào)控因子TFEb的藥物設(shè)計;高通量小分子藥物篩選惡性皮膚癌靶向蛋白MITF抑制劑。
2001:四川大學優(yōu)秀學生獎學金
2002:四川大學優(yōu)秀學生獎學金
2008:光華獎學金
2010:中國科學技術(shù)大學優(yōu)秀畢業(yè)研究生獎學金
1. Wang J, Fang P, Bennett S, Dai J, Fisher D, Guo M. Structural Modularity of Microphathalimia-associated Transcription Factor in Melanoma. 2016.
2.Wang J, Fang P, Chen X, Guo M. Ap4A induced tetramer forming regulates tumor suppressor function of Hint1. 2016.
3.Wang J, Spicer T, Hodder P, Guo M. High throughput screening development for directly targeting a transcription factor. 2016.
4.Wang J, Gossing M, Fang P, Zimmermann J, Li X, von Mollard GF, Niu L, Teng M. Epsin N-terminal homology domains bind on opposite sides of two SNAREs. Proc Natl Acad Sci U S A. 2011 Jul 26; 108 (30): 12277-82.
5.Wang J, Fang P, Schimmel P, Guo M. Side Chain Independent Recognition of Aminoacyl-Adenylates by the Hint1 Transcription Suppressor. Journal of Physical Chemistry, 2012 Jun 14; 116 (23): 6798-805
6.Ofir-Birin Y, Fang P, Bennett SP, Zhang HM, Wang J, Rachmin I, Shapiro R, Song J, Dagan A, Kim S, Marshall AG, Schimmel P, Yang XL, Nechushtan H, Razin E, Guo M. Structural switch of lysyl-tRNA synthetase function between translation and transcription. Mol. Cell, 2013. 49(1):30-42.
7.Kim DG, Fang P, Wang J, Kang BS, Guo M, Kim S. A genome-destabilizing mutation of AIMP3/p18 at the interface for translational initiation. 2016.
8.Fang P, Wang J, Chen K, Guo, M., Structural adaptation for novel functional regulation through dynamic adjustment in human lysyl-tRNA synthetase. 2016.
9.Kim DG, Lee JY, Kwon NH, Fang P, Zhang Q, Wang J, Young NL, Guo M, Cho HY, Mushtaq AU, Jeon YH, Choi JW, Han JM, Kang HW, Joo JE, Hur Y, Kang W, Yang H, Nam DH, Lee MS, Lee JW, Kim ES, Moon A, Kim K, Kim D, Kang EJ, Moon Y, Rhee KH, Han BW, Yang JS, Han G, Yang WS, Lee C, Wang MW, Kim S. Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction. Nat Chem Biol. 2014. Jan;10(1):29-34.
10.Fang P, Li X, Wang J, Xing L, Gao Y, Niu L, Teng M. Crystal structure of the protein L-isoaspartyl methyltransferase from Escherichia coli. Cell Biochem Biophys, 2010 Dec;58(3):163-7
11.Fang P, Li X, Wang J, Niu L, Teng M. Structural basis for the specificity of the GAE domain of yGGA2 for its accessory proteins Ent3 and Ent5. Biochemistry, 2010 Sep 14;49(36):7949-55
12.Fang P, Wang J, Li X, Guo M, Xing L, Cao X, Zhu Y, Gao Y, Niu L, Teng M. Crystallization and preliminary X-ray analysis of Escherichia coli RNase G. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009 Jun 1;65(Pt 6):586-8
13.Xing L, Zhu Y, Fang P, Wang J, Zeng F, Li X, Teng M, Li X. Crystallization and preliminary crystallographic studies of UbiG, an O-methyltransferase from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Jun 1;67(Pt 6):727-9

