
1997-2002 安徽理工大學(xué)醫(yī)學(xué)院醫(yī)學(xué)學(xué)士?
2002-2007 中科院上海生命科學(xué)研究院 博士?
2008-2014 德國(guó)癌癥研究中心 博士后?
2015-至今 中科院上海有機(jī)化學(xué)研究所/中科院生物與化學(xué)交叉研究中心? 課題組長(zhǎng)
研究血管在衰老和疾病過程中的功能改變。將綜合應(yīng)用下一代測(cè)序技術(shù),高分辨率顯微成像技術(shù),并制備新的動(dòng)物模型用以研究以下問題:?
1. 血管新生過程中,不同血管內(nèi)皮細(xì)胞群體的特性。并篩選新一代特異性的抑制腫瘤血管新生的藥物。?
2. 神經(jīng)退行性疾病過程中,血管功能的改變,并探索基于改善血管內(nèi)皮細(xì)胞功能的治療方法。?
Hu J*, Srivastava K*, Wieland M, Runge A, Mogler C, Besemfelder E, Terhardt D, Vogel MJ, Cao L, Korn C, Bartels S, Thomas M, Augustin HG: Endothelial cell-derived Angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat. Science, 343: 416-419, 2014 (* equal contribution) ?
??? Korn C*, Scholz B*, Hu J, Srivastava K, Wojtarowicz J, Arnsperger T, Adams RH, Boutros M, Augustin HG, Augustin I: Endothelial cell-derived non-canonical Wnt ligands control vascular pruning in angiogenesis. Development, 141: 1757-1766, 2014. (* equal contribution).?
? Runge A, Hu J, Wieland M, Bergeest JP, Mogler C, Gerauld C, Arnold B, Rohr K, Komljenovic, D., Schirmacher P, Goerdt S, Augustin HG: An inducible hepatocellular carcinoma model for preclinical evaluation of antiangiogenic therapy in adult mice. Cancer Research, 74: 4157-4169, 2014.?
Srivastava K*, Hu J*, Korn C, Kapel S, Jugold M, Besemfelder E, Thomas M, Augustin HG: Postsurgical adjuvant tumor therapy by combining anti-Angiopoietin-2 and metronomic chemotherapy effectively limits metastatic progression. Cancer Cell, 26: 880-895, 2014 (* equal contribution).?
Mogler C*, Wieland M*, K?nig C, Hu J, Runge A, Korn K, Besemfelder E, Breitkopf-Heinlein K, Komljenovic D, Dooley Steven, Schirmacher P, Longerich T, Augustin HG: Hepatic Stellate cell expressed Endosialin balances fibrogenesis and hepatocyte proliferation during liver damage. Embo Mol Med, 7: 332-228, 2015, ?
Yang WJ*, Hu J*, Uemura A, Tetzlaff F, Augustin HG, Fischer A: Semaphorin-3C signals through Neuropilin-1 and Plexin-D1 receptors to inhibit pathological angiogenesis. Embo Mol Med, 2015, (in press) (* equal contribution)?

