
2016.6 – Now????? 中國科學(xué)院上海有機化學(xué)研究所生物與化學(xué)交叉研究中心?研究員
2015.4 – 2016.5????哈佛醫(yī)學(xué)院達納法伯癌癥研究所癌癥生物學(xué)系? 研究科學(xué)家
2010.4 – 2015.3?? 哈佛醫(yī)學(xué)院達納法伯癌癥研究所癌癥生物學(xué)系,哈佛醫(yī)學(xué)院生物化學(xué)與分子藥學(xué)系? 博士后
2009.7 - 2009.12??? 中國科學(xué)院上海有機化學(xué)研究所? 助理研究員?
2004.9 - 2009.7?????中國科學(xué)院上海有機化學(xué)研究所? 有機化學(xué)博士
2000.9 - 2004.7?????南京大學(xué)? 化學(xué)學(xué)士
譚立課題組以潛在靶標蛋白結(jié)構(gòu)及功能為導(dǎo)向,研發(fā)新穎、高特異性、高活性的小分子調(diào)節(jié)劑。
以自行研發(fā)的新型調(diào)節(jié)劑作為信號通路探針,進一步研究其靶標蛋白在癌癥、炎癥或神經(jīng)退行性疾病中的病理功能,及作為治療靶點的潛力。
優(yōu)化先導(dǎo)化合物,研發(fā)臨床治療的候選藥物。課題組當前關(guān)注作為維持蛋白質(zhì)穩(wěn)態(tài)的重要組件的靶蛋白——E3連接酶和去泛素化酶及一些激酶靶點。?
羅氏創(chuàng)新化學(xué)獎(2008)
? 南京大學(xué)人民獎學(xué)金 (2002-2003)
1. Li Tan#, Jun Wang#, Junko Tanizaki#, Zhifeng Huang#, Amir R. Aref#, Maria Rusan, Su-Jie Zhu, Yiyun Zhang, Dalia Ercan, Rachel G. Liao, Marzia Capelletti, Wenjun Zhou, Wooyoung Hur, NamDoo Kim, Taebo Sim, Suzanne Gaudet, David A. Barbie, Jing-Ruey Joanna Yeh, Cai-Hong Yun, Peter S. Hammerman*, Moosa Mohammadi*, Pasi A. J?nne*, and Nathanael S. Gray*, Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors, Proceedings of the National Academy of Sciences of the United States of America, 2014, 111(45):E4869-4877.
2. Li Tan#, Koshi Akahane#, Randall McNally, Kathleen M. S. E. Reyskens, Scott B. Ficarro, Suhu Liu, Grit S. Herter-Sprie, Shohei Koyama, Michael J. Pattison, Katherine Labella, Liv Johannessen, Esra A. Akbay, Kwok-Kin Wong, David A. Frank, Jarrod A. Marto, Thomas A. Look, J. Simon C. Arthur, Michael J. Eck, and Nathanael S. Gray*, Development of Selective Covalent Janus Kinase 3 Inhibitors, Journal of Medicinal Chemistry, 2015, 58(16):6589-6606.
3. Li Tan#, Tyzoon Nomanbhoy, Deepak Gurbani, Matthew Patricelli, John Hunter, Jiefei Geng, Lina Herhaus, Jianming Zhang, Eduardo Pauls, Youngjin Ham, Hwan Geun Choi, Ting Xie, Xianming Deng, Sara J. Buhrlage, Taebo Sim, Philip Cohen, Gopal Sapkota, Kenneth D. Westover, and Nathanael S. Gray*, Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2), Journal of Medicinal Chemistry, 2015, 58(1):183-196.
4. Hideki Terai#, Li Tan#, Ellen M. Beauchamp, John M. Hatcher, Qingsong Liu, Matthew Meyerson, Nathanael S. Gray,* and Peter S. Hammerman*, Characterization of DDR2 inhibitors for the treatment of DDR2 mutated non-small cell lung cancer, ACS Chemical Biology, 2015, 10(12):2687–2696.
5. Zhifeng Huang#, Li Tan#, Huiyan Wang#, Yang Liu, Steven Blais, Jingjing Deng, Thomas A. Neubert, Nathanael S. Gray, Xiaokun Li,* and Moosa Mohammadi*, DFG-out mode of inhibition by an irreversible type-1 inhibitor capable of overcoming gate-keeper mutations in FGF receptors, ACS Chemical Biology, 2015, 10(1):299-309.
6. Hyung-Gu Kim#, Li Tan#, Ellen L. Weisberg#, Feiyang Liu#, Peter Canning#, Hwan Geun Choi#, Scott A. Ezell, Hong Wu, Zheng Zhao, Jinhua Wang, Anna Mandinova, James D. Griffin, Alex N. Bullock, Qingsong Liu,* Sam W. Lee,* and Nathanael S. Gray*, Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor, ACS Chemical Biology, 2013, 8(10):2145-2150.
7. Li Tan#, Deepak Gurbani#, Ellen L. Weisberg, John C. Hunter, Lianbo Li, Douglas S. Jones, Scott B. Ficarro, Samar Mowafy, Chun-Pong Tam, Suman Rao, Guangyan Du, James D. Griffin, Peter K. Sorger, Jarrod A. Marto, Kenneth D. Westover*, Nathanael S. Gray*, Structure-guided development of covalent TAK1 inhibitors, Bioorganic & Medicinal Chemistry, 2017, 25(3):838-846.
8. Li Tan#, Deepak Gurbani#, Ellen L. Weisberg#, Douglas S. Jones#, Suman Rao, William D. Singer, Faviola M. Bernard, Samar Mowafy, Annie Jenney, Guangyan Du, Atsushi Nonami, James D. Griffin, Douglas A. Lauffenburger, Kenneth D. Westover*, Peter K. Sorger*, Nathanael S. Gray*, Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors, Bioorganic & Medicinal Chemistry, 2017, 25(4):1320-1328.
9. Li Tan#, Dawei Ma*, Total synthesis of salinamide A: a potent anti-inflammatory bicyclic depsipeptide, Angewandte Chemie International Edition, 2008, 47(19):3614-3617.

