教育經歷：
2009.9-2017.6? ? 北京大學 基礎醫(yī)學八年制本博連讀
2009.9-2014.6? ? 北京大學 基礎醫(yī)學 醫(yī)學學士學位
2011.9-2014.6? ? 北京大學 漢語言文學 文學學士雙學位
2014.9-2017.6? ? 北京大學 醫(yī)學生物化學與分子生物學 博士學位
工作經歷
2017.11-2021.6? ?哈佛大學 博士后
2021.8-至今? ? ?中國科學院生物與化學交叉中心 研究員，課題組長
李婉津課題組致力于研究調控多種疾病如脊髓側索硬化癥、阿茲海默癥等神經退行性疾病及腫瘤耐藥過程中炎癥反應的表觀遺傳及基因轉錄調控機制，聯(lián)合分子生物學、細胞生物學和生物信息學等手段對疾病中轉錄活動中的染色質重塑異常和組蛋白修飾變化進行鑒定和探索。
課題組具體研究方向為：
1.細胞死亡、炎癥的關鍵調控分子在細胞核內的表觀遺傳調控功能鑒定；
2.調節(jié)關鍵蛋白細胞核質轉運的小分子藥物的發(fā)現(xiàn)和作用機理研究；
3.人類疾病中染色質重塑復合物的基因突變所造成病理變化的分子機制；
4.腫瘤耐藥過程中的染色質重塑和長鏈非編碼RNA調控機制。
1.??????Li, W., Shan, B., Zou, C., Wang, H., Zhang, M., Zhu, H., Naito, M. G., Xu, D., Manuel, V. J., Mifflin, L., Ravits, J. & Yuan, J. Nuclear RIPK1 promotes chromatin remodeling for mediating inflammatory response.?Cell Res, in review (2021).
2.??????Tao, P.#, Sun, J.#, Wu, Z.#, Wang, S.#, Wang, J.#,?Li, W.#, Pan, H., Bai, R., Zhang, J., Wang, Y., Lee, P. Y., Ying, W., Zhou, Q., Hou, J., Wang, W., Sun, B., Yang, M., Liu, D., Fang, R., Han, H., Yang, Z., Huang, X., Li, H., Deuitch, N., Zhang, Y., Dissanayake, D., Haude, K., McWalter, K., Roadhouse, C., MacKenzie, J. J., Laxer, R. M., Aksentijevich, I., Yu, X.*, Wang, X.*, Yuan, J.* & Zhou, Q.* A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1.?Nature?577, 109-114, doi:10.1038/s41586-019-1830-y (2020).
3.??????Li, W., Zhang, Z., Liu, X., Cheng, X., Zhang, Y., Han, X., Zhang, Y., Liu, S., Yang, J., Xu, B., He, L., Sun, L., Liang, J. & Shang, Y. The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancer.?J Clin Invest?127, 3421-3440, doi:10.1172/JCI94233 (2017).
4.??????Naito, M. G., Xu, D., Amin, P., Lee, J., Wang, H.,?Li, W., Kelliher, M., Pasparakis, M. & Yuan, J. Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke.?Proc Natl Acad Sci U S A?117, 4959-4970, doi:10.1073/pnas.1916427117 (2020).
5.??????Su, Z., Dziedzic, S. A., Hu, D., Barrett, V. J., Broekema, N.,?Li, W., Qian, L., Jia, N., Ofengeim, D., Najafov, A., Zhu, H., Knipe, D. M. & Yuan, J. ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner.?Cell Death Differ?26, 1077-1088, doi:10.1038/s41418-018-0215-3 (2019).
6.??????Xu, D., Jin, T., Zhu, H., Chen, H., Ofengeim, D., Zou, C., Mifflin, L., Pan, L., Amin, P.,?Li, W., Shan, B., Naito, M. G., Meng, H., Li, Y., Pan, H., Aron, L., Adiconis, X., Levin, J. Z., Yankner, B. A. & Yuan, J. TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging.?Cell?174, 1477-1491 e1419, doi:10.1016/j.cell.2018.07.041 (2018).
7.??????He, L., Liu, X., Yang, J.,?Li, W., Liu, S., Liu, X., Yang, Z., Ren, J., Wang, Y., Shan, L., Guan, C., Pei, F., Lei, L., Zhang, Y., Yi, X., Yang, X., Liang, J., Liu, R., Sun, L. & Shang, Y. Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis.?Cell Res?28, 934-951, doi:10.1038/s41422-018-0079-6 (2018).
8.??????Xie, G., Liu, X., Zhang, Y.,?Li, W., Liu, S., Chen, Z., Xu, B., Yang, J., He, L., Zhang, Z., Jin, T., Yi, X., Sun, L., Shang, Y. & Liang, J. UTX promotes hormonally responsive breast carcinogenesis through feed-forward transcription regulation with estrogen receptor.?Oncogene?36, 5497-5511, doi:10.1038/onc.2017.157 (2017).
9.??????Liu, Y., Liu, S., Yuan, S., Yu, H., Zhang, Y., Yang, X., Xie, G., Chen, Z.,?Li, W.,?Xu, B., Sun, L., Shang, Y. & Liang, J. Chromodomain protein CDYL is required for transmission/restoration of repressive histone marks.?J Mol Cell Biol?9, 178-194, doi:10.1093/jmcb/mjx013 (2017).
10.???Liu, X., Si, W., Liu, X., He, L., Ren, J., Yang, Z., Yang, J.,?Li, W., Liu, S., Pei, F., Yang, X. & Sun, L. JMJD6 promotes melanoma carcinogenesis through regulation of the alternative splicing of PAK1, a key MAPK signaling component.?Mol Cancer?16, 175, doi:10.1186/s12943-017-0744-2 (2017).
11.???Liu, S., Yu, H., Liu, Y., Liu, X., Zhang, Y., Bu, C., Yuan, S., Chen, Z., Xie, G.,?Li, W., Xu, B., Yang, J., He, L., Jin, T., Xiong, Y., Sun, L., Liu, X., Han, C., Cheng, Z., Liang, J. & Shang, Y. Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis.?Mol Cell?67, 853-866 e855, doi:10.1016/j.molcel.2017.07.011 (2017).
12.???Li, L., Liu, X., He, L., Yang, J., Pei, F.,?Li, W., Liu, S., Chen, Z., Xie, G., Xu, B., Ting, X., Zhang, Z., Jin, T., Liu, X., Zhang, W., Yuan, S., Yang, Z., Wu, C., Zhang, Y., Yang, X., Yi, X., Liang, J., Shang, Y. & Sun, L. ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin.?Nat Commun?8, 691, doi:10.1038/s41467-017-00702-5 (2017).
13.???Chen, Z., Gui, B., Zhang, Y., Xie, G.,?Li, W., Liu, S., Xu, B., Wu, C., He, L., Yang, J., Yi, X., Yang, X., Sun, L., Liang, J. & Shang, Y. Identification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly.?J?Biol Chem?292, 18113-18128, doi:10.1074/jbc.M117.797357 (2017).
14.???Zhang, Y., Zhang, D., Li, Q., Liang, J., Sun, L., Yi, X., Chen, Z., Yan, R., Xie, G.,?Li, W., Liu, S., Xu, B., Li, L., Yang, J., He, L. & Shang, Y. Nucleation of DNA repair factors by FOXA1 links DNA demethylation to transcriptional pioneering.?Nat Genet?48, 1003-1013, doi:10.1038/ng.3635 (2016).
15.???Shan, L., Zhou, X., Liu, X., Wang, Y., Su, D., Hou, Y., Yu, N., Yang, C., Liu, B., Gao, J., Duan, Y., Yang, J.,?Li, W., Liang, J., Sun, L., Chen, K., Xuan, C., Shi, L., Wang, Y. & Shang, Y. FOXK2 Elicits Massive Transcription Repression and Suppresses the Hypoxic Response and Breast Cancer Carcinogenesis.?Cancer Cell?30, 708-722, doi:10.1016/j.ccell.2016.09.010 (2016).
16.???Li, L., Shi, L., Yang, S., Yan, R., Zhang, D., Yang, J., He, L.,?Li, W., Yi, X., Sun, L., Liang, J., Cheng, Z., Shi, L., Shang, Y. & Yu, W. SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability.?Nat Commun?7, 12235, doi:10.1038/ncomms12235 (2016).
17.???Yan, R., He, L., Li, Z., Han, X., Liang, J., Si, W., Chen, Z., Li, L., Xie, G.,?Li, W., Wang, P., Lei, L., Zhang, H., Pei, F., Cao, D., Sun, L. & Shang, Y. SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer.?Genes Dev?29, 672-685, doi:10.1101/gad.254292.114 (2015).
18.???Si, W., Huang, W., Zheng, Y., Yang, Y., Liu, X., Shan, L., Zhou, X., Wang, Y., Su, D., Gao, J., Yan, R., Han, X.,?Li, W., He, L., Shi, L., Xuan, C., Liang, J., Sun, L., Wang, Y. & Shang, Y. Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis.?Cancer Cell?27, 822-836, doi:10.1016/j.ccell.2015.04.011 (2015).
19.???Yang, X., Yang, J., Li, L., Sun, L., Yi, X., Han, X., Si, W., Yan, R., Chen, Z., Xie, G.,?Li, W., Shang, Y. & Liang, J. PAAT, a novel ATPase and trans-regulator of mitochondrial ABC transporters, is critically involved in the maintenance of mitochondrial homeostasis.?FASEB J?28, 4821-4834, doi:10.1096/fj.14-254045 (2014).
20.???Wang, F., He, L., Huangyang, P., Liang, J., Si, W., Yan, R., Han, X., Liu, S., Gui, B.,?Li, W., Miao, D., Jing, C., Liu, Z., Pei, F., Sun, L. & Shang, Y. JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation.?PLoS Biol?12, e1001819, doi:10.1371/journal.pbio.1001819 (2014).
21.???Han, X., Gui, B., Xiong, C., Zhao, L., Liang, J., Sun, L., Yang, X., Yu, W., Si, W., Yan, R., Yi, X., Zhang, D.,?Li, W., Li, L., Yang, J., Wang, Y., Sun, Y. E., Zhang, D., Meng, A. & Shang, Y. Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking system in neural development.?Mol Cell?55, 482-494, doi:10.1016/j.molcel.2014.06.006 (2014).
